EPIDEMIOLOGY OF ACTIVATED PROTEIN C RESISTANCE AND FACTOR V LEIDEN MUTATION IN THE MEDITERRANEAN REGION

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Mehrez Mehrez M. Jadaon *
(*) Corresponding Author:
Mehrez Mehrez M. Jadaon | mehrez@hsc.edu.kw

Abstract

Venous thromboembolic disorders (VTE) are serious disorders with high morbidity and mortality rates. Many genetic and acquired risk factors were identified to cause VTE The most common genetic risk factor is Factor V Leiden mutation (FVL). FVL was found in high percentage of populations of Caucasian origin but was almost absent in non-Caucasians. It was also reported in populations living in North Africa and the Middle East.  This review article briefly explains FVL and how it causes VTE, the distribution of FVL worldwide, and then it elaborates on the epidemiology of FVL in the Mediterranean Region and how this brought speculations that FVL might have originated in the Eastern Mediterranean area.


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Author Biography

Mehrez Mehrez M. Jadaon, Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait

  Department of Medical Laboratory Sciences, Faculty of Allied Health Sciences, Kuwait University, Kuwait   P.O. Box 31470 – Sulaibekaht 90805 – Kuwait Tel.: (965) 6664 3485 Fax: (965) 2498 3835          mehrezmls99@yahoo.com