Methotrexate induced lung injury in a patient with primary CNS lymphoma: A case report

puneet chhabra, arjun dutt law, dr vikas suri, dr pankaj malhotra, dr subhash varma
  • puneet chhabra
    junior resident department of internal medicine PGIMER CHANDIGARH 160012,
  • arjun dutt law
    senior resident department of internal medicine PGIMER CHANDIGARH 160012,
  • dr vikas suri
    assistant professor department of internal medicine PGIMER CHANDIGARH 160012,
  • dr subhash varma
    HOD and professor department of internal medicine PGIMER chandigarh,

Abstract

Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate . Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.

Keywords

methotrexate, lung in jury, primary CNS lymphoma

Full Text:

PDF
HTML
Submitted: 2014-06-13 09:33:00
Published: 2012-04-02 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
110

Views:
PDF
144
HTML
2617

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Ā 

The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006] is owned by the U.C.S.C. and it is published by PAGEPressĀ®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185