Bone marrow involvement in a patient with alpha heavy chain disease:Response to tetracycline treatment

Zahit Bolaman, Irfan Yavasoglu, Gokhan Sargin, Gurhan Kadikoylu, Firuzan Kacar Doger
  • Zahit Bolaman
    Adnan Menderes University Medical Faculty, Division of Hematology, Turkey
  • Irfan Yavasoglu
    Adnan Menderes University Medical Faculty, Division of Hematology, Turkey
  • Gurhan Kadikoylu
    Adnan Menderes University Medical Faculty, Division of Hematology, Turkey
  • Firuzan Kacar Doger
    Adnan Menderes University Medical Faculty, Division of Pathology, Turkey

Abstract

A 28-year-old man admitted with abdominal pain, weight loss and diarrhea. Barium x-ray studies showed segmentation, dilatation of bowel loops, mucosal folds thickening and delayed intestinal transit. Biopsy specimens histologically revelaed villous atrophy and plasmacytic infiltration limited to mucosa and submucosa. Computed tomography showed multiple lymphadenopathy in the abdomen. Serum protein electropheresis and immunoelectropheresis indicated elevated IgA concentration. Bone marrow aspiration and biopsy revealed presence of lymphoplasmacytic infiltration. Immunohistochemical analysis of the intestine, lymph node showed positivity for CD45, CD-79, CD-20.  After tetracycline treatment the patient’s symptoms, abdominal lymphadenopathy and bone marrow infiltration disappeared and IgA concentration was normalized.

Keywords

alpha heavy chain; immunoproliferative small intestinal disease; Mediterranean lymphoma; tetracycline

Full Text:

PDF
HTML
Submitted: 2014-06-13 09:33:15
Published: 2012-05-07 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
195

Views:
PDF
71
HTML
2598

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185