IMMUNOGLOBULIN GENE REPERTOIRE IN CHRONIC LYMPHOCYTIC LEUKEMIA: INSIGHT INTO ANTIGEN SELECTION AND MICROENVIRONMENTAL INTERACTIONS

Efterpi Kostareli, Maria Gounari, Andreas Agathangelidis, Kostas Stamatopoulos
  • Efterpi Kostareli
    1. Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece 2. Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece, Italy
  • Maria Gounari
    Affiliation not present
  • Andreas Agathangelidis
    Affiliation not present
  • Kostas Stamatopoulos
    1. Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece 2. Institute of Agrobiotechnology, Center for Research and Technology Hellas, Thessaloniki, Greece, | kostas.stamatopoulos@gmail.com

Abstract

Immunogenetic analysis of the B cell receptors (BcRs) has been a richly rewarding field for unraveling the pathogenesis of human lymphomas, including CLL. A biased immunoglobulin gene repertoire is seen as evidence for selection of CLL progenitor cells by antigen. Additional corroborative evidence is provided by the differential prognosis of cases with distinct mutational status of the clonotypic BcRs. However, perhaps the strongest immunogenetic “evidence for the importance of interactions with microenvironment in driving CLL development and evolution is the existence of subsets of patients with quasi-identical, stereotyped BcRs, collectively accounting for a remarkable one-third of the entire cohort. These observations have been instrumental in shaping the notion that CLL ontogeny is functionally driven and dynamic, rather than a simple stochastic process. From a clinical perspective, ample evidence indicates that immunogenetic information can be used for the biologically and clinically rational categorization of CLL, with important potential implications for basic, translational and clinical research.

Keywords

Chronic Lymphoid Leukemia, Immunogenetc , B cell receptors

Full Text:

PDF
HTML
Submitted: 2014-06-13 09:30:04
Published: 2012-08-09 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
419

Views:
PDF
115
HTML
4725

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006] is owned by the U.C.S.C. and it is published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185