Flow Cytometry Method as a Diagnostic Tool for Pleural Fluid Involvement in a Patient with Multiple Myeloma

Muzaffer Keklik, Serdar Sivgin, Cigdem Pala, Celalettin Eroglu, Gulsah Akyol, Leylagul Kaynar, Mustafa Yavuz Koker, Demet Camlica, Ali Unal, Mustafa Cetin, Bulent Eser
  • Muzaffer Keklik
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri,, Turkey | muzafferkeklik@yahoo.com
  • Serdar Sivgin
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Cigdem Pala
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Celalettin Eroglu
    Department of Radiation Oncology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Gulsah Akyol
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Leylagul Kaynar
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Mustafa Yavuz Koker
    Flow Cytometry Unit, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Demet Camlica
    Flow Cytometry Unit, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Ali Unal
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Mustafa Cetin
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey
  • Bulent Eser
    Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri, Turkey

Abstract

Multiple myeloma is a malignant proliferation of plasma cells that mainly affects bone marrow. Pleural effusions secondary to pleural myelomatous involvement have rarely been reported in the literature. As it is rarely detected, we aimed to report a case in which pleural effusion of a multiple myeloma was confirmed as true myelomatous involvement by flow cytometry method. A 52-years old man presented to our clinic with chest and back pain lasting for 3 months. On the chest radiography, pleural fluid was detected in left hemithorax. Pleural fluid flow cytometry was performed. In the flow cytometry, CD56, CD38 and CD138 found to be positive, while CD19 was negative. True myelomatous pleural effusions are very uncommon, with fewer than 100 cases reported worldwide. Flow cytometry is a potentially useful diagnostic tool for clinical practice. We presented our case; as it has been rarely reported, although flow cytometer is a simple method for detection of pleural fluid involvement in multiple myeloma.

Keywords

flow cytometry; multiple myeloma, pleural effusion

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Submitted: 2014-06-13 09:34:00
Published: 2012-10-03 00:00:00
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