An Urologic Face of Chronic Lymphocytic Leukemia:Sequential Prostatic and Penis Localization

Giovanni D'Arena, Roberto Guariglia, Oreste Villani, Maria Carmen Martorelli, Giuseppe Pietrantuono, Giovanna Mansueto, Giuseppe Patitucci, Emilio Imbriani, Tommaso Masciandaro, Ludovica Borgia, Giulia Vita, Fiorella D'Auria, Teodora Statuto, Pellegrino Musto
  • Giovanni D'Arena
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy | giovannidarena@libero.it
  • Roberto Guariglia
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Oreste Villani
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Maria Carmen Martorelli
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Giuseppe Pietrantuono
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Giovanna Mansueto
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Giuseppe Patitucci
    Pathology Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Emilio Imbriani
    Urology Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Tommaso Masciandaro
    Urology Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy,
  • Ludovica Borgia
    Pathology Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Giulia Vita
    Pathology Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Fiorella D'Auria
    Laboratory of Clinical Research and Advanced Diagnostics, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Teodora Statuto
    Laboratory of Clinical Research and Advanced Diagnostics, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy
  • Pellegrino Musto
    Hematology and Stem Cell Transplantation Unit, IRCCS Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture (PZ), Italy, Italy

Abstract

We report a patient with chronic lymphocytic leukemia (CLL) in whom a leukemic involvement of prostate and penis occurred in the advanced phase of his disease. Obstructive urinary symptoms were indicative of prostatic CLL infiltration, followed by the occurrence of an ulcerative lesion on the glans. Histologic examination confirmed  the  neoplastic B-cell infiltration. Both localizations responded to conventional treatments. A review of the literature confirms that leukemic involvement of the genito-urinary system is   uncommon in CLL patients. However, such an involvement should be considered in CLL patients with urologic symptoms and a long history of the disease.

Keywords

chronic lymphocytic leukemia, prostate, penis, infiltration

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Submitted: 2014-06-13 09:59:45
Published: 2013-01-02 00:00:00
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