PREVALENCE OF HPV HIGH-RISK GENOTYPES IN THREE COHORTS OF WOMEN IN OUAGADOUGOU (BURKINA FASO)

Theodora M. Zohoncon, Jacques Simpore
  • Theodora M. Zohoncon
    Affiliation not present
  • Jacques Simpore
    Prof. Jacques SIMPORE, Professeur Titulaire de Génétique et de Biologie Moléculaires Recteur de l'Université saint Thomas d'Aquin, USTA (www.usta.bf) Université de Ouagadougou UFR/SVT, Département de Biochimie Microbiologie Directeur du Centre de Recherche Biomoléculaire, Pietro Annigoni,CERBA/LABIOGENE Directeur du Laboratoire Biomédical de Saint Camille Tel. +226 50361232 ; +226 50397168, Burkina Faso | simpore@hotmail.com

Abstract

The development of cervical cancer is ​​associated with high-risk Human papilloma viruses (HPV-HR). In sub-Saharan Africa cervical cancer is the most common cancer among women and the leading cause of death attributed to malignant tumors. This study aims to identify HPV genotypes within the 30'S and 50'S HPV families found in two previous studies from our laboratory, and to determine the prevalence of twelve HPV-HR genotypes in a population of women in Ouagadougou.

The twelve HPV-HR genotypes were determined by real-time multiplex PCR, in 180 samples from the general population and among a group of HIV-1 infected women.

The most common genotypes found were HPV 35 (29.4%) and HPV 31 (26.1%) of the 30’S family, and HPV 52 (29.4%) and HPV 58 (20.6%) of the 50'S family. Multiple infections of HPV-HR were observed in 78.03% of infected women.

The frequencies of HPV genotypes from the 30'S and 50'S families were higher, while the genotypes HPV-16 and18 were lower among the women in our study.

 

Keywords

Cervical cancer, multiplex real time PCR, HIV, Burkina Faso

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Submitted: 2014-06-13 09:58:26
Published: 2013-09-01 00:00:00
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