Acute Cytomegalovirus infection as a cause of venous thromboembolism

Raffaella Lissandrin, Francesco Mojoli, Fausto Baldanti, Enrico Brunetti, Michela Pascarella, Maria Teresa Giordani, Francesca Rinaldi
  • Raffaella Lissandrin
    Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, via Brambilla 74, 27100 Pavia, Italy.Department of Infectious Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy, Italy
  • Francesco Mojoli
    Clinical-Surgical, Diagnostic and Pediatric Sciences Department, Section of Anesthesia and Intensive Care 1, University of Pavia, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy, Italy
  • Fausto Baldanti
    Molecular Virology Unit, Virology and Microbiology Department, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy, Italy
  • Enrico Brunetti
    Department of Infectious Diseases, , IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy, Italy
  • Michela Pascarella
    Microbiology and Virology Service, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy, Italy
  • Maria Teresa Giordani
    Infectious and Tropical Diseases Unit, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy, Italy
  • Francesca Rinaldi
    Department of Infectious Diseases, , IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy, Italy | francescarinaldi16@yahoo.it

Abstract

Acute Human Cytomegalovirus (HCMV) Infection  is an unusual cause of venous thromboembolism, a potentially life-threatening condition. Thrombus formation can occur at the onset of the disease or later during recovery and may also occur in the absence of acute HCMV hepatitis. It is likely due to both vascular endothelium damage caused by HCMV and impairment of the clotting balance caused by the virus itself. Here we report on two immunocompetent women with splanchnic thrombosis that occurred during the course of acute HCMV infection. Although the prevalence of venous thrombosis in patients with acute HCMV infection is unknown, physicians should be aware of its occurrence, particularly in immune-competent patients presenting with fever and unexplained abdominal pain referred to the splanchnic region.

Keywords

HCMV , portal vein thrombosis, ultrasound, immunocompetent host

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Submitted: 2014-07-21 14:10:59
Published: 2014-05-30 00:00:00
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