EPIDEMIOLOGICAL OVERVIEW OF HODGKIN LYMPHOMA ACROSS THE MEDITERRANEAN BASIN

Massimiliano Salati, Marina Cesaretti, Matteo Macchia, Mufid El Mistiri, Massimo Federico
  • Massimiliano Salati
    Department of Diagnostic, Clinical and Public Healt Medicine, University of Modena and Reggio Emilia, Italy
  • Marina Cesaretti
    Department of Diagnostic, Clinical and Public Healt Medicine, University of Modena and Reggio Emilia, Italy
  • Matteo Macchia
    Department of Diagnostic, Clinical and Public Healt Medicine, University of Modena and Reggio Emilia, Italy
  • Mufid El Mistiri
    Hamad Medical Corporation, National Center for Cancer Care and Research (NCCCR), Qatar., Qatar
  • Massimo Federico
    Department of Diagnostic, Clinical and Public Healt Medicine, University of Modena and Reggio Emilia, Italy | massimo.federico@unimore.it

Abstract

Hodgkin Lymphoma (HL) is an uncommon neoplasm of B-cell origin with an incidence that varies significantly by age, sex, ethnicity, geographic location and socioeconomic status. This complex pattern was also found to be replicated among Mediterranean basin populations. HL incidence rates progressively decreased from industrialized European countries such as France (ASR=2.61) and Italy (ASR=2.39) to less developed nations such as Albania (ASR=1.34) and Bosnia Herzegovina (ASR=1.1). Regarding HL mortality we have found that countries with the lowest incidence rates show the highest number of deaths from this cancer and viceversa. Finally, a wide gap in terms of survival was showed across the Mediterranean basin with survival rates ranged from 82.3% and 85.1% among Italian men and women, to 53.3 % and 59.3% among Libyan men and women, respectively. Factors such as the degree of socio-economic development, the exposure to risk factors westernization-related, the availability of diagnostic practices along with different genetic susceptibilities to HL may explain its variation across Mediterranean countries. Furthermore, the lack of health resources decisively contribute to the poor prognosis recorded in less developed region. In the future, the introduction of appropriate and accessible treatment facilities along with an adequate number of clinical specialists in the treatment of HL and other cancers are warranted in order to improve the outcomes of affected patients and treat a largely curable type of cancer in disadvantaged regions.

Keywords

Epidemiology; Hodgkin lymphoma; Mediterranean Area

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Submitted: 2014-07-21 14:06:36
Published: 2014-06-29 00:00:00
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