NUTRITIONALLY VARIANT STREPTOCOCCI BACTEREMIA IN CANCER PATIENTS: A RETROSPECTIVE STUDY, 1999-2014

Abraham Tareq Yacoub, Jayasree Krishnan, Ileana M. Acevedo, Joseph Halliday, John Norman Greene
  • Abraham Tareq Yacoub
    H. Lee Moffitt Cancer Center and Research Institute Division of Infectious Disease and International Medicine, United States
  • Jayasree Krishnan
    H. Lee Moffitt Cancer Center and Research Institute Division of Infectious Disease and International Medicine, United States
  • Ileana M. Acevedo
    University of South Florida, Morsani College of Medicine Division of Infectious Disease and International Medicine, United States
  • Joseph Halliday
    University of South Florida, Morsani College of Medicine Division of Infectious Disease and International Medicine, United States
  • John Norman Greene
    Section Chief, Division of Infectious Diseases and Tropical Medicine - Moffitt Cancer Center, Tampa FL Professor of Medicine, United States | john.greene@moffitt.org

Abstract

Backgound

Nutritionally variant Streptococci (NVS), Abiotrophia and Granulicatella are implicated in causing endocarditis and blood stream infections more frequently than other sites of infection. Neutropenia and mucositis are the most common predisposing factors for infection with other pathogens in cancer patients. In this study we investigated the clinical characteristics of NVS bacteremia in cancer patients and identified risk factors and outcomes associated with these infections.

 Materials and Methods

We retrospectively reviewed all cases of NVS bacteremia occurring from June 1999 to April 2014 at H. Lee Moffitt Cancer Center and Research Institute. The computerized epidemiology report provided by the microbiology laboratory identified thirteen cancer patients with NVS bacteremia. We collected data regarding baseline demographics and clinical characteristics such as age, sex, underlying malignancy, neutropenic status, duration of neutropenia, treatment, and outcome.

Results

Thirteen patients were identified with positive NVS blood stream infection. Ten patients (77%) had hematologic malignancies, including chronic lymphocytic leukemia (CLL) (1), multiple myeloma (MM) (1), acute myelogenous leukemia (AML) (4), and non Hodgkin’s lymphoma (NHL) (4).  The non-hematologic malignancies included esophageal cancer (2) and bladder cancer (1).

Conclusion

NVS should be considered as a possible agent of bacteremia in cancer patients with neutropenia and a breach in oral, gastrointestinal and genitourinary mucosa (gingivitis/mucositis).

Keywords

Nutritionally variant streptococci; Bacteremia; Neutropenia; Immunocompromised; Endocarditis

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