DEMOGRAPHICAL, VIRO-IMMUNOLOGICAL, CLINICAL AND THERAPEUTICAL CHARACTERISTICS OF HIV INFECTED PATIENTS IN A “EPIDEMIOLOGICALLY UNEXPLORED” REGION OF ITALY (CALABRIA REGION): THE CALABRHIV COHORT.

Maria Concetta Postorino, Filippo Luciani, Carmelo Mangano, Maria Stella Carpentieri, Paolo Scerbo, Armando Priamo, Giuseppina Berardelli, Roberto Marino, Alfredo Vallone, Nicola Serrao, Vincenzo Pisani, Chiara Costa, Albano Terremoto, Giuseppe Foti, Lucio Cosco, Massimo Calderazzo, Domenico Corigliano, Preziosa Scordo, Carlo Torti, Alessio Strazzulla
  • Maria Concetta Postorino
    Infectious Diseases Unit, “Magna Graecia” University, Catanzaro, Italy | cettypostorino@gmail.com
  • Filippo Luciani
    Affiliation not present
  • Carmelo Mangano
    Affiliation not present
  • Maria Stella Carpentieri
    Affiliation not present
  • Paolo Scerbo
    Affiliation not present
  • Armando Priamo
    Affiliation not present
  • Giuseppina Berardelli
    Affiliation not present
  • Roberto Marino
    Affiliation not present
  • Alfredo Vallone
    Affiliation not present
  • Nicola Serrao
    Affiliation not present
  • Vincenzo Pisani
    Affiliation not present
  • Chiara Costa
    Affiliation not present
  • Albano Terremoto
    Affiliation not present
  • Giuseppe Foti
    Affiliation not present
  • Lucio Cosco
    Affiliation not present
  • Massimo Calderazzo
    Affiliation not present
  • Domenico Corigliano
    Affiliation not present
  • Preziosa Scordo
    Affiliation not present
  • Carlo Torti
    Affiliation not present
  • Alessio Strazzulla
    Affiliation not present

Abstract

Background and Objectives

 

HIV epidemics may differ among epidemiological contexts. We aimed at constructing an HIV clinical cohort whose main epidemiological, clinical and therapeutical characteristics are described (the CalabrHIV cohort, Calabria Region, Southern Italy).

 

Methods

 

The CalabrHIV cohort includes all HIV patients on active follow-up in all infectious disease centers in the Calabria Region as at October 2014. All information were recorded in a common electronic database. Not-infectious co-morbidities (such as cardiovascular diseases, bone fractures, diabetes, renal failure and hypertension) were also studied.

 

Results

 

548 patients (68% males; 63% aged <50 years) were included in the CalabrHIV cohort. Major risk factors: sexual transmission (49%) and intravenous drug use (34%). 39% patients had HCV and/or HBV co-infection. An high percentage of late presenters was observed (68.4% patients with CD4+ nadir <350/mm3and 38.5% patients with AIDS at baseline). 83% patients on HAART  had actually undetectable HIV-RNA. Hypertension was the most frequent co-morbidity (21.5%). Multi-morbidity was more frequent in >50 years-old patients than in <50 years-old ones (30% vs. 6%; p<0.0001). Co-morbidity was more frequent in HCV and/or HBV co-infected than in HIV mono-infected patients (46.6% vs. 31.7%: p=0.0006).

 

Conclusion

 

This cohort presentation study sheds light, for the first time, on HIV patients’ characteristics in the Calabria Region. Despite a small number of officially reported cases, the size of the cohort was substantial. We showed that HIV infected patients with chronic hepatites, were affected by concomitant not-infectious co-morbidities more than the HIV mono-infected individuals. New HCV treatments are eagerly awaited.

Keywords

HIV, AIDS, antiretroviral therapy, late presentation, HCV co-infection

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Submitted: 2015-03-21 15:02:55
Published: 2015-10-08 00:00:00
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