A strange case of Malaria in a Nigerian native boy.

Paola Magro, Ilaria Izzo, Barbara Saccani, Salvatore Casari, Silvio Caligaris, Lina Rachele Tomasoni, Alberto Matteelli, Annamaria Lombardi, Antonella Meini, Francesco Castelli
  • Paola Magro
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Ilaria Izzo
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy | izzo.ilaria@hotmail.it
  • Barbara Saccani
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Salvatore Casari
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Silvio Caligaris
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Lina Rachele Tomasoni
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Alberto Matteelli
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Annamaria Lombardi
    University Department of Pediatrics, University of Brescia and Spedali Civili General Hospital, Brescia, Italy, Italy
  • Antonella Meini
    University Department of Pediatrics, University of Brescia and Spedali Civili General Hospital, Brescia, Italy,
  • Francesco Castelli
    University Department of Infectious and Tropical Diseases, University of Brescia and Spedali Civili General Hospital, Brescia, Italy,

Abstract

The protective role of SCT in malaria endemic areas has been proved and prevalence of HbS gene in malaria endemic areas is high. Splenic infarction is a well-known complication of SCT, rarely associated with malaria. A Nigerian boy was admitted to our ward after returning from his country of origin, for P. falciparum malaria. He underwent abdominal US for upper right abdominal pain, showing cholecystitis and multiple splenic abscesses. Empiric antibiotic therapy was undertaken. Bartonella, Echinococcus, Entamoeba serologies, blood cultures, Quantiferon test, coproparasitologic exam were negative; endocarditis was excluded. He underwent further blood exams and abdomen MRI, confirming the presence of signal alterations areas, with radiographic appearance of recent post-infarction outcomes. Hemoglobin electrophoresis showed a percentage of HbS of 40.6% and a diagnosis of SCT was made.

Splenic infarction should be taken into account in patients with malaria and localized abdominal pain.  Moreover, diagnosis of SCT should be considered.

Keywords

Malaria, Sickle Cell Trait, Splenic Infarction

Full Text:

PDF
HTML
Submitted: 2016-12-12 14:17:17
Published: 2017-03-01 00:00:00
Search for citations in Google Scholar
Related articles: Google Scholar

References

Luzzatto L. Sickle Cell Anaemia and Malaria. Mediter J Hematol Infect Dis 2012, 4(1): e2012065.

Russo G et al. Italian Guidelines for the Sickle Cell Disease in Pediatrics. AIEOP. Article available at http://www.aieop.org/files/files_htmlarea/tutto%20giu12.pdf last accessed on November 12th, 2016.

Kark J. Sickle cell trait. Article available at http://sickle.bwh.harvard.edu/sickle_trait.html, last accessed on November 12th, 2016.

Hwang JH, Lee CS. Malaria-Induced Splenic Infarction. Am. J. Trop. Med. Hyg., 2014;91(6):1094–1100.

Cinquetti G, Banal F, Rondel C, et al. Splenic infarction during Plasmodium ovale acute malaria: first case reported. Malar J 2010;9: 288.

Abstract views:
469

Views:
PDF
82
HTML
336

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2017 Mediterranean Journal of Hematology and Infectious Diseases

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

The Mediterranean Journal of Hematology and Infectious Diseases [eISSN 2035-3006] is owned by the U.C.S.C. and it is published by PAGEPress®, Pavia, Italy. All credits and honors to PKP for their OJS.
 
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185