PREVALENCE AND AETIOLOGY OF BACTEREMIA IN FEBRILE CHILDREN WITH SICKLE CELL DISEASE AT A NIGERIA TERTIARY HOSPITAL

Biobele Jotham Brown, Hannah O Dada-Adegbola, Catherine Trippe, Olufunmilayo Olopade
  • Biobele Jotham Brown
    Department of Paediatrics, University College Hospital Ibadan/ College of Medicine, University of Ibadan Ibadan, Nigeria, Nigeria | biobelebrown@hotmail.com
  • Hannah O Dada-Adegbola
    Department of Medical Microbiology University College Hospital/ College of Medicine, University of Ibadan Ibadan, Nigeria
  • Catherine Trippe
    3. University of Chicago Pritzker School of Medicine, Chicago, IL, United States
  • Olufunmilayo Olopade
    Section of Hematology and Oncology, Department of Medicine, University of Chicago, Chicago, IL, United States

Abstract

Background & Objectives: As a result of immune defects in Sickle cell disease (SCD), affected individuals are prone to infection from encapsulated bacterial pathogens like Streptococcus Pneumoniae. Studies on the etiological agents of bacteremia in children with SCD in Nigeria are few and have revealed a spectrum of organisms that is different from those recorded in other parts of the world.  

Aim and Objectives: The objectives of this study were to determine the prevalence of bacteremia, etiological agents and antibiotic susceptibility pattern in febrile children with SCD attending the University College Hospital (UCH), Ibadan, Nigeria.

Methods: The study was cross-sectional and took place at the Department of Pediatrics of the UCH, Ibadan. Children with SCD, ages 0-17 years presenting with axillary temperature ≥ 380C were enrolled after obtaining informed consent.  History was obtained and complete physical examination performed after which blood was collected for culture and antibacterial susceptibility tests.

Results: A total of 116 children were studied of which 69 (59.5%) were males, 111 (95.7%) were of the Hemoglobin SS phenotype and 5 (4.3%) of the Hemoglobin SC phenotype. Bacteremia was present in 16 (13.8%) of the 116 children. Gram negative bacteria constituted 10 (62.5%) of all isolates, while the predominant isolates were Klebsiella pneumonia 4, (25%) and Staphylococcus aureus, 4 (25%). Over 80% of the isolates were susceptible to Ceftriaxone, Amikacin and Meropenem.

Conclusions Klebsiella pneumonia and Staphylococcus aureus are the predominant causes of bacteremia in children with SCD in Ibadan, contrary to findings in western countries.

Keywords

Anemia: bacterial infection; sickle cell

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Submitted: 2017-02-26 21:23:49
Published: 2017-06-20 00:00:00
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