Original Articles
Vol. 10 (2018): Review Articles, Original Articles, Scientific Letters, Case Reports
https://doi.org/10.4084/mjhid.2018.021

CLINICAL AND HEMATOLOGICAL PROFILE OF PATIENTS WITH DENGUE FEVER AT A TERTIARY CARE HOSPITAL – AN OBSERVATIONAL STUDY

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Received: January 10, 2018
Accepted: February 5, 2018
Published: March 1, 2018
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Dengue fever, Dengue hemorrhagic fever, Dengue shock syndrome, Thrombocytopenia
Infectious Disease, Vector borne disease

Authors

Vishal Vishnu Tewari
docvvt_13@hotmail.com
Army Hospital (Referral & Research), New Delhi, India, India.
Kunal Tewari
Base Hospital, New Delhi, India, India.
Ritu Mehta
Base Hospital, New Delhi, India, India.

Abstract

Background: Dengue is a major health issue with seasonal rise in dengue fever cases imposing an additional burden on hospitals, necessitating bolstering of services in the emergency department, laboratory with creation of additional dengue fever wards.

Objectives: To study the clinical and hematological profile of dengue fever cases presenting to a hospital.

Methods: Patients with fever and other signs of dengue with either positive NS1 antigen test or IgM or IgG antibody were included. Age, gender, clinical presentation, platelet count and hematocrit were noted and patients classified as dengue fever (DF), dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Duration of hospitalization, bleeding manifestations, requirement for platelet component support and mortality were recorded.

Results: There were 443 adults and 57 children between 6 months to 77 year age. NS1 was positive in 115 patients (23%). Fever (99.8%) and severe bodyache (97.4%) were the commonest presentation. DF was seen in 484 (96.8 %), DHF in 10 (2%) and DSS in 6 cases (1.2%). OPD treatment was needed in 412 (82%) and hospitalization in 88 (18%). Intravenous fluid resuscitation was needed in 16 (3.2%) patients. Thrombocytopenia was seen in 335 (67%) patients at presentation. Platelet transfusion was needed in 46 (9.2%). PRC transfusion was given in 3 patients with DF and 10 of DHF. Death occurred in 03 DSS and 2 DHF patients.

Conclusions: Majority of DF cases can be managed on OPD basis. DHF and DSS carry high mortality. Hospitals can analyze annual data for resource allocation for capacity expansion.

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Ethics Approval

Original Article
Vishal Vishnu Tewari, Army Hospital (Referral & Research), New Delhi, India

Dr Vishal Vishnu Tewari

MD (Pediatrics), DNB (Neonatology), MNAMS

Associate Professor 

Department of Pediatrics

Army Hospital (Referral & Research)

New Delhi - 110010

Kunal Tewari, Base Hospital, New Delhi, India

Dr Kunal Tewari

MD (Anesthesiology), Diploma Emergency Med, FACEE

Assistant Professor

Department of Anesthesiology and Critical Care

Base Hospital, New Delhi - 110010

Ritu Mehta, Base Hospital, New Delhi, India

Dr Ritu Mehta

MD (Pathology), Fellowship in Oncopathology

Assistant Professor

Department of Pathology

Base Hospital, New Delhi - 110010

How to Cite



“CLINICAL AND HEMATOLOGICAL PROFILE OF PATIENTS WITH DENGUE FEVER AT A TERTIARY CARE HOSPITAL – AN OBSERVATIONAL STUDY” (2018) Mediterranean Journal of Hematology and Infectious Diseases, 10(1), p. e2018021. doi:10.4084/mjhid.2018.021.