Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma

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Maria Lucia De Luca
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome,

Laura Lombardi
Service D’Hématologie, Hôpital Simone Veil, Troyes

Germana Tartaglia
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

Francesca Fazio
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

Alessio Di Prima
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

Laura Cesini
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

Alessandra Serrao
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

Martina Canichella
Hematology, Department of Translational and Precision Medicine, Sapienza University of Rome

Alessandro Pulsoni
Division of Hematology, Dipartimento di Biotecnologie Cellulari ed Ematologia, La Sapienza University, via Benevento 6, 00161 Rome, Italy.

Keywords

HCV, B-NHL, lipoma-like Marginal Zone Lymphoma, Direct-acting antiviral (DAAs)

Abstract

In 2010 a new entity termed “lipoma-like” HCV related marginal zone B-NHL was described.
The etiological link between HCV infection and B-NHL has been extensively investigated in several epidemiological, biological and therapeutic studies and large experiences in literature demonstrated indolent lymphoma’s regression after antiviral therapy.
HCV-related indolent NHL response to interferon-ribavirin-based antiviral therapy is well documented, while evidence of the efficacy of interferon-free direct-acting antivirals (DAAs) in this subset of lymphoma is also currently increasing. In this article we report two cases of HCV-related subcutaneous “lipoma-like” Marginal Zone B-cell lymphoma, treated with DAAs. Sustained virological response (SVR) with reduction of MZL localizations, persisting to date, were obtained in both patients. These data originally demonstrate the efficacy of DAAs in this rare entity.

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Published
Aug 29, 2019
DOI https://doi.org/10.4084/mjhid.2019.053

Article Details

How to Cite

De Luca, M. L. (2019) “Response to Interferon-Free Direct Antivirals (DAAS) Treatment in HCV-Related Subcutaneous Lipoma-Like Marginal Zone B-Cell Lymphoma”, Mediterranean Journal of Hematology and Infectious Diseases, 11(1), p. e2019053. doi: 10.4084/mjhid.2019.053.
Issue
Vol. 11 No. 1 (2019): Review Articles, Original Articles, Scientific Letters, Case Reports, Letters to Editor.
Section
Case Reports

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