Case Reports
Vol. 7 (2015): Review Series, Original Articles, Case Reports
https://doi.org/10.4084/mjhid.2015.006

Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment

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Received: August 29, 2014
Accepted: November 15, 2014
Published: August 1, 2015
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Sickle Cell Anaemia- Aspergillus Infection-Bone Marrow Transplant
Hematology-Infectious Diseases

Authors

Katia Paciaroni
k.paciaroni@gmail.com
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Gioia De Angelis
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Cristiano Gallucci
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Cecilia Alfieri
Michela Ribersani
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Andrea Roveda
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Antonella Isgrò
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Marco Marziali
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Ivan Pietro Aloi
Departments of Surgery, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, .
Alessandro Inserra
Departments of Surgery, Ospedale Pediatrico Bambino Gesù, IRCCS, Rome, Italy, .
Javid Gaziev
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Pietro Sodani
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Guido Lucarelli
International Centre for Transplantation in Thalassemia and Sickle Cell Anaemia, Mediterranean Institute of Haematology, Policlinic of “Tor Vergata” University, Rome, Italy, .
Sickle Cell Anaemia (SCA) is the most common inherited blood disorder and is associated with severe morbidity and decreased survival. Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) is the only curative approach. Nevertheless the decision to perform a marrow transplant includes the risk of major complications  and mortality transplant related. The infections represent the main cause of mortality for SCA patients undergoing transplant. Invasive Pulmonary Aspergillosis (IPA) is a devastating opportunistic infection and remains a significant cause of morbidity and mortality in HSCT recipients. Data regarding IPA in the setting of SCA are lacking. In the present report,  we describe a patient with SCA who developed IPA after allogeneic bone marrow transplant. The fungal infection was treated by systemic antifungal therapy in addition to the surgery, despite  mild chronic GVHD and with continuing immunosuppression therapy. This case shows that IPA occurring in bone marrow recipient with SCA can be successful treated

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“Invasive Pulmonary Aspergillosis in a Sickle Cell Patient Transplant Recipient: A Successful Treatment” (2015) Mediterranean Journal of Hematology and Infectious Diseases, 7(1), p. e2015006. doi:10.4084/mjhid.2015.006.