Monoclonal Gammopathy of Undetermined Significance Disguised as Chronic Neutrophilic Leukemia

Main Article Content

Monique A Hartley-Brown
Lubomir Sokol
Gisela L Caceres
Mohammed A Hussein
Alan List
Javier Pinilla-Ibarz

Keywords

myeloma, neutrophilia, plasma cell disorder

Abstract

A 60-year-old woman with a medical history of diabetes mellitus, osteoporosis, peripheral vascular disease, and hypertension who was otherwise asymptomatic but continued showing elevated neutrophil levels sought a second opinion at our facility. Serum protein immunoelectrophoresis with immunofixation revealed an immunoglobulin A (IgA)-? monoclonal gammopathy concentration of 1305 mg/dL (normal 80-350 mg/dL) but relatively normal concentrations of IgG of 840 mg/dL (620-1400 mg/dL) and IgM of 36 mg/dL (45-250 mg/dL). Clonal analysis revealed a polyclonal expression pattern in all cell types analyzed. We concluded that our patient’s neutrophilia may have been due to the underlying monoclonal gammopathy. This is the first case in the literature of a patient with monoclonal gammopathy of undetermined significance presenting with neutrophilia, suggestive of chronic neutrophilic leukemia (CNL).  Patients with CNL have a poor prognosis; therefore, it is important to distinguish diagnostically between CNL and the less severe prognosis of monoclonal gammopathy of undetermined significance.

Downloads

Download data is not yet available.
Abstract 572 | PDF Downloads 330 HTML Downloads 290

Most read articles by the same author(s)