REGULATORY T-CELLS IN CHRONIC LYMPHOCYTIC LEUKEMIA

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Giovanni D'arena *
Giovanni Rossi
Barbara Vannata
Silvia Deaglio
(*) Corresponding Author:
Giovanni D'arena | giovannidarena@libero.it

Abstract

Regulatory T-cells (Tregs) constitute a small subset of cells that are actively involved in maintaining self-tolerance, in immune homeostasis and in antitumor immunity. They are thought to play a significant role in the progression of cancer and are generally increased in patient with chronic lymphocytic leukemia (CLL). Their number correlates with more aggressive disease status and is predictive of the time to treatment, as well. Moreover, it is now clear that dysregulation in Tregs cell frequency and/or function may result in a plethora of autoimmune diseases, including multiple sclerosis, type 1 diabetes mellitus, myasthenia gravis, systemic lupus erythematosis, autoimmune lymphoproliferative disorders, rheumatoid arthritis, and psoriasis. Efforts are made aiming to develop approaches to deplete Tregs or inhibit their function in either cancer and autoimmune disorders.


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Author Biography

Giovanni D'arena

), Giovanni Rossi (2), Barbara Vannata (3), Silvia Deaglio (4), Giovanna Mansueto (1), Fiorella D’Auria (5), Teodora Statuto (5), Vittorio Simeon (6), Laura De Martino (7), Aurelio Marandino (7), Giovanni Del Poeta (8), Vincenzo De Feo (7), Pellegrino Musto (1)

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