Flow Cytometry Method as a Diagnostic Tool for Pleural Fluid Involvement in a Patient with Multiple Myeloma

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Muzaffer Keklik *
Serdar Sivgin
Cigdem Pala
Celalettin Eroglu
Gulsah Akyol
Leylagul Kaynar
Mustafa Yavuz Koker
Demet Camlica
Ali Unal
Mustafa Cetin
Bulent Eser
(*) Corresponding Author:
Muzaffer Keklik | muzafferkeklik@yahoo.com

Abstract

Multiple myeloma is a malignant proliferation of plasma cells that mainly affects bone marrow. Pleural effusions secondary to pleural myelomatous involvement have rarely been reported in the literature. As it is rarely detected, we aimed to report a case in which pleural effusion of a multiple myeloma was confirmed as true myelomatous involvement by flow cytometry method. A 52-years old man presented to our clinic with chest and back pain lasting for 3 months. On the chest radiography, pleural fluid was detected in left hemithorax. Pleural fluid flow cytometry was performed. In the flow cytometry, CD56, CD38 and CD138 found to be positive, while CD19 was negative. True myelomatous pleural effusions are very uncommon, with fewer than 100 cases reported worldwide. Flow cytometry is a potentially useful diagnostic tool for clinical practice. We presented our case; as it has been rarely reported, although flow cytometer is a simple method for detection of pleural fluid involvement in multiple myeloma.

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Author Biographies

Muzaffer Keklik, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri,

MD

Serdar Sivgin, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

assistant of proffessor

Cigdem Pala, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

MD

Celalettin Eroglu, Department of Radiation Oncology, Faculty of Medicine, Erciyes University, Kayseri

assistant of proffessor

Gulsah Akyol, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

MD

Leylagul Kaynar, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

assistant of proffessor

Mustafa Yavuz Koker, Flow Cytometry Unit, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

assistant of proffessor

Demet Camlica, Flow Cytometry Unit, Faculty of Medicine, Erciyes University, Kayseri

technician of laboratory

Ali Unal, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

proffessor

Mustafa Cetin, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

proffessor

Bulent Eser, Erciyes Stem Cell Transplantation Hospital, Department of Hematology, Faculty of Medicine, Erciyes University, Kayseri

proffessor