Acute Cytomegalovirus infection as a cause of venous thromboembolism

Main Article Content

Raffaella Lissandrin
Francesco Mojoli
Fausto Baldanti
Enrico Brunetti
Michela Pascarella
Maria Teresa Giordani
Francesca Rinaldi *
(*) Corresponding Author:
Francesca Rinaldi | francescarinaldi16@yahoo.it

Abstract

Acute Human Cytomegalovirus (HCMV) Infection  is an unusual cause of venous thromboembolism, a potentially life-threatening condition. Thrombus formation can occur at the onset of the disease or later during recovery and may also occur in the absence of acute HCMV hepatitis. It is likely due to both vascular endothelium damage caused by HCMV and impairment of the clotting balance caused by the virus itself. Here we report on two immunocompetent women with splanchnic thrombosis that occurred during the course of acute HCMV infection. Although the prevalence of venous thrombosis in patients with acute HCMV infection is unknown, physicians should be aware of its occurrence, particularly in immune-competent patients presenting with fever and unexplained abdominal pain referred to the splanchnic region.


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Author Biographies

Raffaella Lissandrin, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, via Brambilla 74, 27100 Pavia, Italy.Department of Infectious Diseases, IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy

Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, via Brambilla 74, 27100 Pavia, Italy.

Medical Doctor, Research Scholarship

Francesco Mojoli, Clinical-Surgical, Diagnostic and Pediatric Sciences Department, Section of Anesthesia and Intensive Care 1, University of Pavia, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy

Clinical-Surgical, Diagnostic and Pediatric  Sciences Department, Section of Anesthesia and Intensive Care 1, University of Pavia, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy

Medical Doctor

Fausto Baldanti, Molecular Virology Unit, Virology and Microbiology Department, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy

Molecular Virology Unit, Virology and Microbiology Department, IRCCS San Matteo Hospital Foundation, Viale Golgi 19, 27100 Pavia, Italy

Medical Doctor

Enrico Brunetti, Department of Infectious Diseases, , IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy

Department of Infectious Diseases, , IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy

Medical Doctor

Michela Pascarella, Microbiology and Virology Service, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy

Microbiology and Virology Service, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy

Medical Doctor

Maria Teresa Giordani, Infectious and Tropical Diseases Unit, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy

Infectious and Tropical Diseases Unit, San Bortolo Hospital, Viale Rodolfi 37, 36100 Vicenza, Italy

Francesca Rinaldi, Department of Infectious Diseases, , IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy

Department of Infectious Diseases, , IRCCS San Matteo Hospital Foundation, University of Pavia, Viale Golgi 19, 27100 Pavia, Italy

Medical Doctor