1 Department of Medicine, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun
2 Department of Pathology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun
3 Department of Pediatrics, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun
4 Presently in Department of Medicine, All India Institute of Medical Sciences, Rishikesh
5 Department of Microbiology, Himalayan Institute of Medical Sciences, Swami Rama Himalayan University, Dehradun
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Background & Objectives: Classically associated with Plasmodium (P.) falciparum,
neurological complications in severe malaria is associated with
increased morbidity and mortality. However, reports implicate the long
considered benign P. vivax
for causing severe malaria as well. We aimed to analyse the cerebral
complications in malaria, and study if there is a species-related
difference in the presentation and outcomes.
Materials and Methods
|Table 1. Comparison of demographic, clinical, haematological and biochemical parameters, complications and outcomes of acute malaria with and without neurological involvement.|
|Table 2. Comparison of complications and outcomes of cerebral malaria due to different species.|
ConclusionsNeurological complications in malaria, classically caused in P. falciparum infections are increasingly being observed in P. vivax infections. The situation is alarming with vivax constituting the major burden of malaria in north India, little recognition of its malignant potential compounded by the almost comparable complications and outcomes. Our study may also prove to be an initiator for further research into possible genetic alterations that the parasite or its carrier may have incurred due to decades of insecticide use, injudicious use of conventional antimalarials, industrialization and ecological transformations and/ or possible co-infection with unrecognized viruses.