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infectious agents appear to provide a proliferative signal --
“antigen-drive” – that could be implicated in the pathogenesis of
various type of Non-Hodgkin Lymphoma (NHL). A classical model of the
infection-driven lymphoproliferative disorder is Helicobacter
pylori-induced gastric MALT lymphoma, where antibiotic therapy allows
the eradication of both the infectious agent and the clonal B-cell
expansion. Following the footsteps of this example, several
retrospective studies have found a correlation with other pathogens and
B-cell Lymphomas, adding new relevant information about pathogenesis
and laying the groundwork for chemotherapy-free treatments.
Role of Infection in other Lymphomas
|Table 1. Links reported in the literature between Follicular Lymphoma and infectious agents.|