1 Unit of Hematology, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
2 University of Siena, Siena, Italy.
3 Unit of Neuroimaging and Neurointervention, Department of Neurological and Sensorineural Sciences, Azienda Ospedaliera Università Senese, "Santa Maria alle Scotte" University and NHS Hospital, Siena, Italy.
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nervous system (CNS) relapse is an infrequent but severe complication
for DLBCL patients, associated with poor prognosis. Intravenous
prophylaxis with high-dose methotrexate has shown promising results but
is rarely feasible in elderly and/or nephropathic patients.
|Figure 1. Neuroradiological follow-up: a) iodine contrast-enhanced computed tomography axial image obtained in 2016, March, at relapse; b) and c) gadolinium-enhanced T1-weighted magnetic resonance axial images obtained after the 2nd and the 6th cycle, respectively.|