1 Department of Translational Medicine & Centre for Thrombosis and Haemostasis, Malmö, Lund University, Sweden.
2 Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden.
3 Coagulation Unit, Haematology Centre, Karolinska University Hospital, Stockholm, Sweden.
4 Hemostasis Department and Hemophilia Centre, Blood Transfusion Institute of Serbia.
5 Clinical Centre of Serbia & Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
6 Coagulation Research, Institute for Molecular Medicine and Surgery, Karolinska Institute & Department of Clinical Chemistry, Karolinska University Hospital, Stockholm, Sweden.
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thrombin-generation tests are available, but few have been directly
compared. Our primary aim was to investigate the correlation of two
thrombin generation tests, thrombin generation assay-calibrated
automated thrombogram (TGA-CAT) and INNOVANCE ETP, to factor VIII
levels (FVIII:C) in a group of patients with hemophilia A.
Material and Methods
|Table 1. Correlation coefficient (r) for ETP and AUC to FVIII:C in all patients and grouped by disease severity.|
|Figure 1. Patients grouped by severity of
hemophilia A and plotted against ETP for both methods, TGA-CAT Malmö
and ETP INNOVANCE (AUC).
|Figure 2. Before normalization: Observations within the green dashed cone represent a ±10% or less difference between ETP values of Stockholm and Malmö results. 29% of the observations lie in the ±10% cone of acceptance. After normalization: Observations within the green dashed cone represent ±10% or less difference between normalized ETP values of Stockholm and Malmö results. 41% of the observations lie in the ±10% cone of acceptance.|
|Table 2. Level of agreement between Malmö and Stockholm TGA-CAT parameters, before and after normalization.|
Grant SupportJ. P. Antovic has granted unrestricted grant from Baxter and has received lecture honoraria from Stago, Siemens, Sysmex, Roche, Baxter and NovoNordisk. None of the other authors declare any conflict of interest.