1 Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar Saba, Israel.
2 Pediatric Hematology Unit, Emek Medical Center, Afula, Israel.
3 The Ruth and Baruch Faculty of Medicine, Technion – Israel Institute of Technology, Haifa, Israel.
4 Hematology Laboratory, Emek Medical Center, Afula, Israel.
* Passed away before manuscript submission.
** Personal collaboration.
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major is a severe disease with high morbidity. The world prevalence of
carriers is around 1.5–7%. The present study aimed to find a reliable
formula for detecting β-thalassemia carriers using an extensive
database of more than 22,000 samples obtained from a homogeneous
population of childbearing age women with 3161 (13.6%) of β-thalassemia
carriers and to check previously published formulas.
|Table 1. Differentiation between β-thalassemia Trait and normal individuals or iron-deficient subjects, summary of the formulas published in the literature.|
|Figure 1. Total number of subjects initially included in the study and final number of subjects analyzed. *Samples with all red cell index values (Hgb, Hct, RBC, MCV, MCH, MCHC and RDW).|
|Table 2. Red cell values for non-β-thalassemia and β-thalassemia Trait women.|
|Table 3. Calculation of the results of the present data for the different published formulas. Subjects with Hgb > 90 g/l.|
|Table 4. Calculation of the results of the present data for the different published formulas. Subjects with Hgb < 90g/l.|
|Figure 2. Single vector machine algorithm calculated formula.|