Arzouma Paul Yooda1,2,3, Serge Theophile Soubeiga1,2, K. Yacouba Nebie3, Birama Diarra1, Salam Sawadogo3, Abdoul Karim Ouattara1,2, Dorcas Obiri-Yeboah4, Albert Theophane Yonli1,2, Issoufou Tao1,2, Pegdwende Abel Sorgho1,2, Honorine Dahourou3 and Jacques Simpore1,2.
of Molecular Biology and Molecular Genetics (LABIOGENE) UFR/SVT,
University Ouaga I Prof. Joseph KI-ZERBO, 03 BP 7021 Ouagadougou
03, Burkina Faso.
2 Biomolecular Research Center Pietro Annigoni (CERBA), 01 BP 364 Ouagadougou 01, Burkina Faso.
3 National Blood Transfusion Center (CNTS), 01 BP 5372 Ouagadougou 01, Burkina Faso.
4 Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Ghana
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Background and Objective:
The improved performance of serological tests has significantly reduced
the risk of human immunodeficiency and hepatitis B and C viruses
transmission by blood transfusion, but there is a persistence of
residual risk. The objective of this study was to evaluate the impact
of multiplex PCR in reducing the risk of residual transmission of these
viruses in seronegative blood donors in Burkina Faso.
Our study showed a high residual risk of HBV transmission through blood
transfusion. Due to the high prevalence of blood-borne infections in
Burkina Faso, we recommend the addition of multiplex PCR to serologic
tests for optimal blood donation screening.
Material and Methods
|Table 1. Seroprevalences of HIV, HBV and HCV according to socio-demographic characteristics of blood donors at CRTS / O.|
|Table 2. Distribution of HBV DNA according to the socio-demographic characteristics of the 38 donors screened positive for multiplex PCR.|