1 Section of
Hematology, Cancer Research and Cell Biology Laboratory, Department of
Medicine, University of Verona, Verona, Italy.
2 Pediatrics Section, Department of Surgical, Odontostomatological and Maternal-Infantile Sciences, University of Verona, Verona, Italy.
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Nile virus is a zoonotic agent causing life-threatening encephalitis in
a proportion of infected patients. Older age, immunosuppression, and
mutations in specific host genes (e.g., CCR5 delta-32 mutation)
predispose to neuroinvasive infection. We report on two cases of severe
West Nile encephalitis in recently-treated, different-aged, chronic
lymphocytic leukemia patients. Both patients developed high-grade fever
associated with severe neurological impairment. The younger one
harboured germ-line CCR5 delta-32 mutation, which might have played a
role in the pathogenesis of its neuroinvasive manifestations.
|Table 1. Reported cases of WNV encephalitis in haematological patients.|