Review Articles
Vol. 11 No. 1 (2019): Review Articles, Original Articles, Scientific Letters, Case Reports, Letters to Editor.
THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: April 3, 2019
Accepted: May 15, 2019
Accepted: May 15, 2019
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Authors
The Notch pathway plays a key role in several processes including stem-cell self-renewal, proliferation, and cell differentiation. Several studies identified recurrent mutations in hematological malignancies making Notch one of the most desirable target in leukemia and lymphoma. The Notch signaling mediates resistance to therapy and controls cancer stem cells supporting the development of on-target therapeutic strategies to improve patients’ outcome. In this brief review, we outline the therapeutic potential of targeting Notch pathway in T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia and mantle cell lymphoma.
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We would recommend these colleagues as potential referees:
Prof. Cristina Mecucci, M.D.; Ph.D.
University of Perugia
cristina.mecucci@unipg.it
Dr. Sabina Chiaretti
University “La Sapienza” of Roma
chiaretti@bce.uniroma1.it
Prof. Cristina Mecucci, M.D.; Ph.D.
University of Perugia
cristina.mecucci@unipg.it
Dr. Sabina Chiaretti
University “La Sapienza” of Roma
chiaretti@bce.uniroma1.it
Ethics Approval
Hematological malignancies, targeted therapySupporting Agencies
This work was supported by an AIRC Start-up Investigator Grant (n. 17107 G.R.), Fondazione Cariparma (3576/2017, 0180/2018 G.R.), Fondazione Grande Ale Onlus (G.R.), Fondazione Umberto Veronesi Post-doctoral Fellowship (C.S.).How to Cite
“THERAPEUTIC TARGETING OF NOTCH SIGNALING PATHWAY IN HEMATOLOGICAL MALIGNANCIES” (2019) Mediterranean Journal of Hematology and Infectious Diseases, 11(1), p. e2019037. doi:10.4084/mjhid.2019.037.
