1 Infectious diseases and tropical medicine research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
2 Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3 Department of Microbiology, Faculty of Biological Sciences, Shahid Beheshti University, Tehran, Iran.
4 Queen Mary, University of London, The liver unit, London, UK.
| This is an Open Access article distributed
under the terms of the Creative Commons Attribution License
(https://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mutations in the S gene (HBsAg), pre-core (PC), and basic core promoter
(BCP) of the hepatitis B virus (HBV) infection are correlated with
disease progression. This study assessed the frequency of mutations in
the S gene, PC, and BCP regions in chronic hepatitis B (CHB) patients.
Patients and Methods
|Table 1. Demographic, biochemical, and virological data of the patients.|
|Table 2. Frequencies of mutations in precore and core promoter region in strains from patients.|
|Table 3. Frequencies of mutations in surface region in strains from patients.|
|Figure 1. Amino acid mutations within B
cell, T helper (Th) and CTL epitopes of HBs proteins. Amino acids are
designated by single letter code and numbered from the beginning of
|Table 4. P value of HBV genome mutations association with HBV viral load, HBeAg statue and liver function in this study.|
|Figure 2. UPGMA phylogenetic tree of surface genes sequences from 33 HBV strains. The tree rooted with HBV Woolly Monkey (AY226578) sequence. Genetic distances were estimated using the Kimura 2-parameter matrix. Clustering of sequences was supported by 1000 resamplings of the data sets.|