Pediatric Hematology Oncology, Azienda Ospedaliera Universitaria Integrata Verona, Italy.
2 Microbiology and Virology Unit, Azienda Ospedaliera Universitaria Integrata Verona, Italy.
3 Microbiology and Virology Unit, Padova University Hospital, Padova, Italy.
4 Ospedale di San Bonifacio, Azienda AULSS 9 Scaligera, Verona, Italy.
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The antibody titer of vaccine-preventable disease in pediatric patients
who underwent chemotherapy was assessed in order to evaluate the
seroprotection after treatment and the feasibility and the efficacy of
a policy of revaccination.
Material and Methods
|Table 1. Vaccination Protocol of the Pediatric Hematology and Oncology Unit, Verona.|
|Table 2. Demographic and clinical characteristics of study patients.|
|Table 3. Seroprotection of study population at the diagnosis and comparison to vaccination coverage of healthy population of the same median age.|
|Table 4. Rates of lack of protective serum antibody titer in patients tested after chemotherapy.|
|Table 5. Rate of loss of protective antibody titers after chemotherapy in patients tested both before and after chemotherapy.|
|Table 6. Univariate analysis of factors associated with loss of immunity after chemotherapy.|
|Table 7. Comparison between lymphocyte subpopulations in peripheral blood of study patients after chemotherapy and healthy controls.|
|Supplementary table 1. Univariate analysis of the number of lymphocytes in peripheral blood and the loss of protective antibody titers after chemotherapy.|
|Supplementary table 2. Presence of protective antibody titers after application of Vaccination Protocol, after chemotherapy.|
|Supplementary table 3. Vaccine immunity reconstitution in patients with lack of immunity after chemotherapy, after the application of Vaccination Protocol.|