Scientific Letters
Vol. 10 (2018): Review Articles, Original Articles, Scientific Letters, Case Reports
Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: September 13, 2017
Accepted: January 15, 2018
Accepted: January 15, 2018
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Hematology,
Sickle cell anemia
Authors
The SOD2 polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the SOD2 polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (p=0.0321; p=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (p=0.0285; p=0.0090, respectively). These results suggest that the SOD2 polymorphism associated with low SOD activity could be involved in SCA physiopathology.
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Scientific LetterSupporting Agencies
Hospital HEMOPE, FACEPEHow to Cite
“Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia” (2018) Mediterranean Journal of Hematology and Infectious Diseases, 10(1), p. e2018012. doi:10.4084/mjhid.2018.012.
