Review Articles
Vol. 10 (2018): Review Articles, Original Articles, Scientific Letters, Case Reports
https://doi.org/10.4084/mjhid.2018.068

MEGAKARYOCYTE CONTRIBUTION TO BONE MARROW FIBROSIS: MANY ARROWS IN THE QUIVER

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Received: August 15, 2018
Accepted: October 23, 2018
Published: November 1, 2018
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Myeloproliferative Neoplasms, Megakaryocytes

Authors

Alessandro Malara
University of Pavia, Italy.
Vittorio Abbonante
University of Pavia, Italy.
Maria Zingariello
University Campus Bio-Medico, Rome, Italy.
Anna Rita Franco Migliaccio
Alma Mater University, Bologna, Italy.
Alessandra Balduini
alessandra.balduini@unipv.it
University of Pavia, Italy.

In Primary Myelofibrosis (PMF), megakaryocyte dysplasia/hyperplasia determines the release of inflammatory cytokines that, in turn, stimulate stromal cells and induce bone marrow fibrosis. The pathogenic mechanism and the cells responsible for progression to bone marrow fibrosis in PMF are not completely understood. This review article aims to provide an overview of the crucial role of megakaryocytes in myelofibrosis by discussing the role and the altered secretion of megakaryocyte-derived soluble factors, enzymes and extracellular matrices that are known to induce bone marrow fibrosis. Additionally, we describe recent evidences showing that the role of megakaryocytes in tissue fibrosis is not limited to the bone marrow.

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Review Article

Supporting Agencies

AIRC
Alessandro Malara, University of Pavia
Department of MOlecular Medicine
Vittorio Abbonante, University of Pavia
Department of Molecular Medicine
Maria Zingariello, University Campus Bio-Medico, Rome
Unit of Microscopic and Ultrastructural Anatomy, Dept of Medicine
Anna Rita Franco Migliaccio, Alma Mater University, Bologna
Department of Biomedical and Neuromotorial Sciences
Alessandra Balduini, University of Pavia
DEpartment of Molecular Medicine

How to Cite



“MEGAKARYOCYTE CONTRIBUTION TO BONE MARROW FIBROSIS: MANY ARROWS IN THE QUIVER” (2018) Mediterranean Journal of Hematology and Infectious Diseases, 10(1), p. e2018068. doi:10.4084/mjhid.2018.068.