Original Articles
Vol. 14 No. 1 (2022): Review Articles, Original Article, Scientific Letter, Case Reports Letter to the Editor
ENDOTHELIAL BIOMARKERS IN PATIENTS RECOVERED FROM COVID-19 ONE YEAR AFTER HOSPITAL DISCHARGE: A CROSS-SECTIONAL STUDY
Endothelial biomarkers in COVID-19 recoverers one year after hospital discharge.
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: December 4, 2021
Accepted: March 8, 2022
Accepted: March 8, 2022
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Background: COVID-19 is characterized by endothelial dysfunction and is presumed to have long-term cardiovascular sequelae. In this study, we aimed to explore the serum levels of endothelial biomarkers of COVID-19 recovers 1-year after hospital discharge.
Methods: A clinical follow-up study, including 345 COVID-19 survivors from Huanggang, Hubei, and 119 age and gender matched healthy controls were enrolled in the study. A standardized symptom questionnaire, electrocardiogram and Doppler ultrasound of lower extremities, routine blood tests, biochemical and immunological tests were collected, and serum levels of soluble vascular cell adhesion molecule-1(VCAM-1), intercellular cell adhesion molecule-1(ICAM-1), P-selectin, and fractalkine were measured by enzyme-linked immunosorbent assays.
Results: 1-year after discharge, 39% of recovers possessed post-COVID syndromes, while no deep vein thrombosis was detected in all screened. No significant differences in circulatory inflammatory markers (leukocytes, neutrophils, lymphocytes, C-reactive protein and interleukin-6), alanine aminotransferase, estimated glomerular filtration rate, glucose, triglycerides, total cholesterol and D-dimer observed among controls and previously mild or severe infected. Furthermore, serum levels of VCAM-1, ICAM-1, P-selectin, and fractalkine presented no significant differences between survivors and healthy controls.
Conclusions: SARS-CoV-2 infection may not impose a higher risk of long-term cardiovascular sequelae, even for those recovered from severe illness.
KEYWORDS: COVID, ENDOTHELIAL DYSFUNCTION, INFLAMMATORY MARKERS, ADHESION MOLECULES, THROMBOSIS.
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Ethics Approval
Infectious Diseases, COVID-19, Sars-Cov-2Supporting Agencies
Key Research and Development Program of Hunan Province (grant number 2020SK3011)How to Cite
“ENDOTHELIAL BIOMARKERS IN PATIENTS RECOVERED FROM COVID-19 ONE YEAR AFTER HOSPITAL DISCHARGE: A CROSS-SECTIONAL STUDY : Endothelial biomarkers in COVID-19 recoverers one year after hospital discharge”. (2022) Mediterranean Journal of Hematology and Infectious Diseases, 14(1), p. e2022033. doi:10.4084/MJHID.2022.033.
Copyright (c) 2022 Ming Tong, Xiquan Yan, Yu Jiang, Zhaoxia Jin, Shengjiao Zhu, Lianhong Zou, Yanjuan Liu, Qing Zheng, Guoqiang Chen, Ruifeng Gui Gui, Zhilan Zhou, Xiaotong Han, Jiangming He, Siqing Yin, Changchun Ma, Wen Xiao, Yong Zeng, Fang Chen, Yimin Zhu
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
