Rujittika Mungmunpuntipantip1 and Viroj Wiwanitkit2.
1 Private Academic Consultant, Bangkok Thailand ORCID 0000-0003-0078-7897
2 Honorary Professor, Dr DY Patil University, Pune, India ORCID 0000-0003-1039-3728.
Correspondence to: Rujittika Mungmunpuntipantip. Private Academic Consultant, Bangkok Thailand. E-mail: firstname.lastname@example.org
Published: July 1, 2022
Received: April 22, 2022
Accepted: June 18, 2022
Mediterr J Hematol Infect Dis 2022, 14(1): e2022060 DOI 10.4084/MJHID.2022.060
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To the editor
read and followed the publication on the "Efficacy and Safety of
Sinopharm Vaccine for SARS-CoV-2 and breakthrough infections in Iranian
Patients with Hemoglobinopathies: A Preliminary Report".
According to Karimi et al., there were no safety concerns in patients
who received two doses of the Sinopharm Vaccine. While its efficacy was
not optimal due to the lack of effect on new virus variations, the data
show that it appears protective against the severity of COVID-19
infection in patients with hemoglobinopathies. We
all agree that the inactivated COVID-19 vaccination protects against
serious illness. The current report can confirm the safety and efficacy
of certain vaccines with underlying hemoglobinopathies. Hemoglobin E
deficiency is extremely common in our environment, Southeast Asia.
Hemoglobin E carriers account for almost a third of the local
population. The efficacy and safety of the inactivated COVID-19 vaccination have also been shown based on local data,[3,4]
similar to the current report by Karimi et al. According to statistics
on the efficacy of inactivated COVID-19 Vaccine in our scenario, 60.6
percent of patients had seroconversion evaluated by sVNT 4 weeks after
finishing the SV vaccination, which is comparable to patients recovered
from moderate COVID-19 infection (69.0 percent).
The inactivated COVID-19 Vaccine's side effects were typically
well-tolerated and unremarkable. In one-fifth to one-third of vaccine
recipients, pain at the injection site and headache are the two most
common side effects.
It should be concluded
that the inactive COVID-19 Vaccine protects against infection and that
using it to vaccinate persons with underlying hemoglobinopathies poses
no medical risk.
- Karimi M, Zarei T, Haghpanah S, Azarkeivan A,
Naderi M, Matin S, Bazrafshan A, Zahedi Z, Shirkavand A, Pishdad P, De
Sanctis V. Efficacy and Safety of Sinopharm Vaccine for SARS-CoV-2 and
breakthrough infections in Iranian Patients with Hemoglobinopathies: A
Preliminary Report. Mediterr J Hematol Infect Dis. 2022 Mar
1;14(1):e2022026. doi: 10.4084/MJHID.2022.026. eCollection 2022. https://doi.org/10.4084/MJHID.2022.026 PMid:35444764 PMCid:PMC8992638
- Fucharoen S, Weatherall DJ. The hemoglobin E thalassemias. Cold Spring Harb Perspect Med. 2012 Aug 1;2(8):a011734. https://doi.org/10.1101/cshperspect.a011734 PMid:22908199 PMCid:PMC3405827
W, Chantasrisawad N, Puthanakit T, Wacharapluesadee S, Hirankarn N,
Ruenjaiman V, Paitoonpong L, Suwanpimolkul G, Torvorapanit P, Pradit R,
Sophonphan J, Putcharoen O. Short-term immune response after
inactivated SARS-CoV-2 (CoronaVac®, Sinovac) and ChAdOx1 nCoV-19
(Vaxzevria®, Oxford-AstraZeneca) vaccinations in health care workers.
Asian Pac J Allergy Immunol. 2021 Oct 31. https://doi.org/10.1101/2021.08.27.21262721
W, Hunsawong T, Punjasamanvong S, Wongrapee T, Suttha P, Piyaraj P,
Leepiyasakulchai C, Tanathitikorn C, Yoocharoen P, Jones AR,
Mongkolsirichaikul D, Westercamp M, Azziz-Baumgartner E, Mott JA,
Chottanapund S. Anti-SARS-CoV-2 IgG antibody levels among Thai
healthcare providers receiving homologous and heterologous COVID-19
vaccination regimens. Influenza Other Respir Viruses. 2022 Feb 24. https://doi.org/10.2139/ssrn.3990107
S, Khunphon A, Kwangsukstid O, Sapsutthipas S, Wichaidit M, Rojanawiwat
A, Wichuckchinda N, Puangtubtim W, Pimpapai W, Soonthorncharttrawat S,
Wanitchang A, Jongkaewwattana A, Srisutthisamphan K, Phainupong D,
Thawong N, Piboonsiri P, Sawaengdee W, Somsaard T, Ritthitham K,
Chumpol S, Pinyosukhee N, Wichajarn R, Dhepakson P, Iamsirithaworn S,
Phumiamorn S. The Pilot Study of Immunogenicity and Adverse Events of a
COVID-19 Vaccine Regimen: Priming with Inactivated Whole SARS-CoV-2
Vaccine (CoronaVac) and Boosting with the Adenoviral Vector (ChAdOx1
nCoV-19) Vaccine. Vaccines (Basel) . 2022 Mar 30;10(4):536. https://doi.org/10.3390/vaccines10040536 PMid:35455285 PMCid:PMC9028748