1 Hematology, Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
2 Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy.
3 Division of Hematopathology, IEO, European Institute of Oncology IRCCS, 20141 Milan, Italy.
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To the editor
|Figure 1. Histologic features of the B-cell and plasma cell component, consistent with gamma-heavy chain disease. CD138 (A) and CD20 (A, inset) show a mild, interstitial infiltrate made up of mature plasma cells and small B-lymphocytes. The plasma cell component is positive for IgG (B) but does not express light chains (C: kappa; D: lambda).|
|Figure 2. Histologic
features of the T-cell component, consistent with T-cell large granular
lymphocyte lymphoproliferative disorder. CD3 (A)
highlights a discrete interstitial and intrasinusoidal T-cell
component, made up by small cells with prevailing cytotoxic CD8+
phenotype (B: CD4; C: CD8) and partial expression of CD57 (D).
|Figure 3. Serum electrophoresis (A) and serum immunofixation (B).
|Table 1. Clinicopathological features of gamma-HCD associated with T-LGL LPD reported in the literature.