@article{WONG_2016, title={HEMOGLOBIN ANALYSIS IN THE FIRST YEAR OF LIFE}, volume={8}, url={https://www.mjhid.org/mjhid/article/view/2016.012}, DOI={10.4084/mjhid.2016.012}, abstractNote={<p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">Background and Objectives: In newborns and infants during their first year of life, there is a dynamic change in the fraction of hemoglobin (Hb). To apply Hb analysis as a phenotypic diagnosis of thalassemia in newborns and infants, we need normal values of each Hb fraction for reference. </span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;"> </span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">Methods: Seventeen cord bloods from normal deliveries were collected for analysis. One hundred and thirty seven infants from the pediatric outpatient clinic were recruited and were categorized by their ages into a series of short periods (month</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">2 weeks). Both alpha and beta thalassemia carriers detected were excluded. Samples with an Hb level less than 10.0 g/dL were also excluded. The proportion of Hb A (</span></span><span lang="EN-US"><span style="font-size: medium;">a</span></span><sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: small;">2</span></span></sub><span lang="EN-US"><span style="font-size: medium;">b</span></span><sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: small;">2</span></span></sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">), A</span><sub><span style="font-family: Times New Roman; font-size: small;">2</span></sub><span style="font-family: Times New Roman; font-size: medium;"> (</span></span><span lang="EN-US"><span style="font-size: medium;">a</span></span><sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: small;">2</span></span></sub><span lang="EN-US"><span style="font-size: medium;">d</span></span><sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: small;">2</span></span></sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">), and F (</span></span><span lang="EN-US"><span style="font-size: medium;">a</span></span><sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: small;">2</span></span></sub><span lang="EN-US"><span style="font-size: medium;">g</span></span><sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: small;">2</span></span></sub><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">) was obtained from high performance liquid chromatography and analyzed according to its categorized periods. </span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;"> </span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">Results: There were 90 (58.4%) specimens left for evaluation. The percentage of Hb A, A</span><sub><span style="font-family: Times New Roman; font-size: small;">2</span></sub><span style="font-family: Times New Roman; font-size: medium;">, and F gradually changed with increasing age. The percentage of Hb A was 21.14</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">7.04% (mean</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">SD) in cord blood and increased substantially to 83.38</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">1.31% at the sixth month. The level was sustained thereafter. The incremental pattern of Hb A</span><sub><span style="font-family: Times New Roman; font-size: small;">2</span></sub><span style="font-family: Times New Roman; font-size: medium;"> was similar to Hb A. The value was 0.32</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">0.19% at the beginning and reached a plateau with 2.78</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">0.25% at the sixth month. The percentage of Hb F started at 78.39</span><span style="text-decoration: underline;"><span style="font-family: Times New Roman; font-size: medium;">+</span></span><span style="font-family: Times New Roman; font-size: medium;">7.59% in cord blood and decreased rapidly in the first 6 months.</span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;"> </span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;">Conclusions: The data possibly can be applied as quick guidance for interpretation of Hb analysis in newborns and infants during their first year of life.</span></span></p><p><span lang="EN-US"><span style="font-family: Times New Roman; font-size: medium;"> </span></span></p>}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={WONG, PEERAPON}, year={2016}, month={Feb.}, pages={e2016012} }