@article{Yousif_Elagib_2017, title={HAPTOGLOBIN PHENOTYPES AND SUSCEPTIBILITY OF SCHISTOSOMA PARASITES INFECTION IN CENTRAL SUDAN}, volume={9}, url={https://www.mjhid.org/mjhid/article/view/2017.042}, DOI={10.4084/mjhid.2017.042}, abstractNote={<p>Haptoglobin (Hp) is an acute phase protein that binds the free haemoglobin (Hb), thus preventing iron loss and renal damage. Hp also has anti-oxidative and immunomodulatory properties. Three Hp phenotypes have been identified in human: Hp1-1, Hp2-1 and Hp2-2. Hp polymorphisms have been related to susceptibility of various diseases. In this study we aimed to assess the possible association of Hp phenotypes polymorphism to <em>Schistosoma</em> parasites infection in central Sudan. We have investigated the Hp phenotypes polymorphism distribution in the serum of 125 (93 <em>S. mansonai</em>, 13 <em>S. haematobium</em> and 19 infected with both ‘’co-infection’’) parasitologically confirmed infected individuals and 208 healthy individuals served as control. Hp phenotypes have been determined by polyacrylamide gel electrophoresis followed by benzidine staining. Our study revealed that Hp1-1 percentage frequency was significantly higher in infected individuals than healthy control individuals 51% and 26% respectively. Our data suggest that Hp1-1 phenotype may upsurge the susceptibility to <em>Schistosoma</em> parasites infection in central Sudan.</p>}, number={1}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={Yousif, Ashraf Siddig and Elagib, Atif Abdelrahman}, year={2017}, month={Jul.}, pages={e2017042} }