@article{Farias_Mendonça-Belmont_Silva_do Ó_Ferreira_Medeiros_Vasconcelos_Rego_Bezerra_Araujo_et al._2018, title={Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia}, volume={10}, url={https://www.mjhid.org/mjhid/article/view/2018.012}, DOI={10.4084/mjhid.2018.012}, abstractNote={<p>The <em>SOD2</em> polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the <em>SOD2 </em>polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (<em>p</em>=0.0321; <em>p</em>=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (<em>p</em>=0.0285; <em>p</em>=0.0090, respectively). These results suggest that the <em>SOD2 </em>polymorphism associated with low SOD activity could be involved in SCA physiopathology. <strong></strong></p>}, number={1}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={Farias, Isabela Cristina Cordeiro and Mendonça-Belmont, Taciana Furtado and Silva, Andreia Soares and do Ó, Kleyton Palmeira and Ferreira, Felipe Borba and Medeiros, Fernanda Silva and Vasconcelos, Luydson Richardson Silva and Rego, Moacyr Jesus Barreto de Melo and Bezerra, Marcos Andre Cavalcanti and Araujo, Aderson Silva and et al.}, year={2018}, month={Feb.}, pages={e2018012} }