@article{Hasan Khan_Anwar_Agha_Saleh_Ullah_Syed_Raja_2013, title={FACTORS PREDICTING MORBIDITY IN PATIENTS WITH DENGUE FEVER IN A TERTIARY CARE HOSPITAL}, volume={5}, url={https://www.mjhid.org/mjhid/article/view/2013.014}, DOI={10.4084/mjhid.2013.014}, abstractNote={<span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; line-height: 200%;" class="MsoNormal"><span style="font-family: Times New Roman;"><strong><span lang="EN-US" style="line-height: 200%; font-size: 13pt;">Introduction: </span></strong><span lang="EN-US" style="line-height: 200%; font-size: 13pt; mso-bidi-font-weight: bold;">Dengue virus (DENV) affects over half the world’s population in 112 countries, and dengue fever (DF) is the second largest arthropod borne infectious global hazard after malaria with complications like Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS) accounting for significant morbidity and mortality world over.<span style="mso-spacerun: yes;"> </span>Pakistan is significantly affected with DENV infection and to-date no study identifying risk factors associated with complications of DF has been done.</span></span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; line-height: 200%;" class="MsoNormal"><span style="font-family: Times New Roman;"><strong><span lang="EN-US" style="line-height: 200%; font-size: 13pt;">Methods: </span></strong><span lang="EN-US" style="line-height: 200%; font-size: 13pt; mso-bidi-font-weight: bold;">997 confirmed cases of DF were collected in a tertiary care hospital in Lahore, Pakistan and their clinical and biochemical data were collected.<span style="mso-spacerun: yes;"> </span>Univariate, multivariate and logistics regression analysis was performed to identify risk factors associated with development of DHF and DSS.<strong></strong></span></span></p><span style="font-family: Times New Roman; font-size: small;"> </span><p style="margin: 0cm 0cm 0pt; line-height: 200%;" class="MsoNormal"><span style="font-family: Times New Roman;"><strong><span lang="EN-US" style="line-height: 200%; font-size: 13pt;">Results: <span style="mso-spacerun: yes;"> </span></span></strong><span lang="EN-US" style="line-height: 200%; font-size: 13pt; mso-bidi-font-weight: bold;">Bleeding OR </span><span lang="EN-US" style="line-height: 200%; font-size: 13pt;">70.7 (CI 38.4-129.9),<span style="mso-bidi-font-weight: bold;"> deranged liver function test OR </span>1.9 (CI 0.97-0.99), platelet count on admission less than 50,000 x10<sup>9</sup>/L OR </span><span lang="EN-US" style="color: black; line-height: 200%; font-size: 14pt;">0.16 (CI 0.13-0.19), </span><span lang="EN-US" style="line-height: 200%; font-size: 13pt;">presence of urinary red blood cells OR 1.4 (CI 0.179-0.900) and presence of urinary protein OR 1.1 (CI 0.191-0.974)<span style="mso-bidi-font-weight: bold;"> were related to development of DHF and DSS.</span></span></span></p><span style="font-family: Times New Roman; font-size: small;"> </span>}, number={1}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={Hasan Khan, Muhammad Imran and Anwar, Eram and Agha, Adnan and Saleh, Noha and Ullah, Ehsan and Syed, Imran Ali and Raja, Arsalan}, year={2013}, month={Feb.}, pages={e2013014} }