@article{NIPARUCK_2021, title={TREATMENT OUTCOMES AND CLINICAL RELEVANCE IN PATIENTS WITH DOUBLE EXPRESSOR DLBCL: Sirapat Rungwittayatiwat1, Paisarn Boonsakan2, Pichika Chantrathammachart1, Teeraya Puavilai1, Sulada Pukiat1, Sithakom Phusanti1,3, Kochawan Boonyawat1, Pathawut Wacharapornin1, Pantep Angchaisuksiri1, Artit Ungkanont1,3, Suporn Chuncharunee1 Pimjai Niparuck1}, volume={13}, url={https://www.mjhid.org/mjhid/article/view/4709}, DOI={10.4084/MJHID.2021.063}, abstractNote={<p><strong>Background</strong>: Double-expressor lymphoma (DEL) was found accounting for 20- 30% of DLBCL. We conducted this study to analyze the survival, the clinical presentation and the factors associated with treatment outcomes in DEL-DLBCL.</p> <p><strong>Methods</strong><strong>:  </strong>A retrospective study of 291 patients diagnosed with DLBCL during January 2015 - December 2018.</p> <p><strong>Results</strong><strong>:</strong> Of the 291 patients, median age was 63 years, germinal center B cell like DLBCL (GCB) and non-GCB subtypes were found in 32% and 68%, respectively. DEL was found in 46% of 264 patients with available immunohistochemistry staining for MYC protein. Patients with DEL was significantly more common in elderly patients (<em>p</em><em>= </em>0.017) and non-GCB subtype (<em>p</em>= 0.006). High serum lactate dehydrogenase (LDH) levels and high Ki-67 index were significantly found in DEL patients than those in non-DEL patients (<em>p</em><em>= </em>0.024 and <em>p</em><em>= </em>0.04, respectively).  3y-OS and 3y-DFS in DEL patients were shorter than those in non-DEL group, 58.7% versus 78.9% (<em>p</em>=0.026) and 58.4% versus 67.7% (<em>p</em>=0.343), respectively. Independent factors affecting both OS and DFS in DEL patients were ECOG 3-4, high LDH level, extranodal involvement> 1 site, DHL, high IPI and stage III-IV.</p> <p><strong>Conclusions</strong><strong>: </strong>High incidence of DEL was observed in this study, especially in patients aged 60 years or older and non-GCB subtype. Patients with DEL showed dismal DFS and OS.</p>}, number={1}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={NIPARUCK, PIMJAI}, year={2021}, month={Oct.}, pages={e2021063} }