@article{Hu_Wu_Cheng_Li_2021, title={EPIDEMIOLOGY AND CLINICAL CHARACTERISTICS OF HENOCH-SCHÖNLEIN PURPURA ASSOCIATED WITH EPSTEIN-BARR VIRUS INFECTION }, volume={13}, url={https://www.mjhid.org/mjhid/article/view/4714}, DOI={10.4084/MJHID.2021.064}, abstractNote={<p><strong>Introduction:</strong> Henoch-Schönlein purpura (HSP) is an immune-mediated vasculitis, and the formation of immune complexes may be triggered by exposure to Epstein-Barr virus (EBV) infection.</p> <p><strong>Methods: </strong>We performed a five-year case-control study to evaluate the epidemiology and clinical characteristics of HSP associated with EBV infection.</p> <p><strong>Results:</strong> The incidence of EBV-triggered HSP was 4.2%, while EBV infection in children with HSP was 0.9%; The EBV-triggered HSP cases had a significantly higher frequency of abdominal pain than the MP-triggered HSP group (χ2 = 8.024, p = 0.005); Significant differences were observed in the duration of abdominal pain (Z = -1.935, <em>p</em> = 0.027) between the two groups; C3 (t = 9.709, <em>p</em> < 0.001), IgA (t = 20.39, <em>p </em>< 0.001) and IgG (t = 6.407, <em>p</em> < 0.001) were significantly increased in the EBV infection group than those in the healthy control group. Notably, significantly higher proportion of CD19 (t = 6.773, <em>p</em> < 0.001) and lower proportion of CD56 (t = 11.13, <em>p</em> < 0.001) was found in EBV infection group compared with healthy control group. The IgA level was higher than that of the non-infectious group (t = 2.162, <em>p</em> = 0.032), but their CD4/CD8 ratio (t = 10.070, <em>p</em> < 0.001) and CD56 proportion (t = 2.096, <em>p</em> = 0.037) were significantly lower.</p> <p><strong>Conclusions: </strong>Both cellular and humoral immunity were involved in the pathogenesis of EBV-triggered HSP, leading to increased production of inflammatory mediators and immunoglobulins. Those events may cause or promote the development of systemic vessel vasculitis.</p>}, number={1}, journal={Mediterranean Journal of Hematology and Infectious Diseases}, author={Hu, Hongbo and Wu, Jiangang and Cheng, Ying and Li, Jian jun}, year={2021}, month={Oct.}, pages={e2021064} }