TY - JOUR AU - Bibas, Michele AU - Antinori, Andrea PY - 2009/12/29 Y2 - 2024/03/28 TI - EBV AND HIV-RELATED LYMPHOMA JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 1 IS - 2 SE - Review Articles DO - 10.4084/mjhid.2009.032 UR - https://www.mjhid.org/mjhid/article/view/2009.032 SP - e2009032 AB - <span style="line-height: 115%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-ansi-language: EN-US; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US">HIV-associated lymphoproliferative disorders represent a heterogeneous group of diseases, arising in the presence of HIV-associated immunodeficiency. The overall prevalence of HIV-associated lymphoma is significantly higher compared to that of the general population and it continues to be relevant even after the wide availability of highly active antiretroviral therapy (HAART) (1). Moreover, they still represent one of the most frequent cause of death in HIV-infected patients. Epstein–Barr virus (EBV), a </span><span style="line-height: 115%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-ansi-language: IT; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">?</span><span style="line-height: 115%; font-family: ";Arial";,";sans-serif";; font-size: 10pt; mso-ansi-language: EN-US; mso-bidi-font-size: 12.0pt; mso-fareast-font-family: Calibri; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;" lang="EN-US">-Herpesviruses, is involved in human lymphomagenesis, particularly in HIV immunocompromised patients. It has been largely implicated in the development of B-cell lymphoproliferative disorders as Burkitt lymphoma (BL), Hodgkin disease (HD), systemic non Hodgkin lymphoma (NHL), primary central nervous system lymphoma (PCNSL), nasopharyngeal carcinoma (NC). Virus-associated lymphomas are becoming of significant concern for the mortality of long-lived HIV immunocompromised patients, and therefore, research of advanced strategies for AIDS-related lymphomas is an important field in cancer chemotherapy. Detailed understanding of the EBV<span style="mso-spacerun: yes;">  </span>lifecycle and related cancers at the molecular level is required for novel strategies of molecular-targeted cancer chemotherapy The linkage of HIV-related lymphoma with EBV infection of the tumor clone has several pathogenetic, prognostic and possibly therapeutic implications which are reviewed herein</span> ER -