TY - JOUR AU - Farias, Isabela Cristina Cordeiro AU - Mendonça-Belmont, Taciana Furtado AU - Silva, Andreia Soares AU - do Ó, Kleyton Palmeira AU - Ferreira, Felipe Borba AU - Medeiros, Fernanda Silva AU - Vasconcelos, Luydson Richardson Silva AU - Rego, Moacyr Jesus Barreto de Melo AU - Bezerra, Marcos Andre Cavalcanti AU - Araujo, Aderson Silva AU - Moura, Patricia Muniz Mendes Freire AU - Anjos, Ana Claudia Mendonça AU - Hatzlhofer, Betânia Lucena Domingues AU - Cavalcanti, Maria do Socorro Mendonça PY - 2018/02/21 Y2 - 2024/03/28 TI - Association of the SOD2 polymorphism (Val6Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 10 IS - 1 SE - Scientific Letters DO - 10.4084/mjhid.2018.012 UR - https://www.mjhid.org/mjhid/article/view/2018.012 SP - e2018012 AB - <p>The <em>SOD2</em> polymorphism Val16Ala TàC influences the antioxidative response. This study investigated the association of the <em>SOD2 </em>polymorphism and superoxide dismutase (SOD) activity with vaso-occlusive crisis (VOC) and acute splenic sequestration (ASS) in children with sickle cell anemia (SCA). One hundred ninety-five children aged 1-9 years old were analyzed. The TC and CC genotypes were associated with lower SOD activity compared with the TT genotype (<em>p</em>=0.0321; <em>p</em>=0.0253, respectively). Furthermore, TC/CC were more frequent in patients with VOC or ASS (<em>p</em>=0.0285; <em>p</em>=0.0090, respectively). These results suggest that the <em>SOD2 </em>polymorphism associated with low SOD activity could be involved in SCA physiopathology. <strong></strong></p> ER -