TY - JOUR AU - Baldini, Simone AU - Rigacci, Luigi AU - Carrai, Valentina AU - Alterini, Renato AU - Fjerza, Rajmonda AU - Bosi, Alberto PY - 2012/06/28 Y2 - 2024/03/28 TI - PATIENTS WITH ? 20 X 109/L PLATELETS AT BASELINE MAY HAVE A PROMPT RESPONSE TO ROMIPLOSTIM DURING THE EARLY PHASE OF TREATMENT: AN ITALIAN SINGLE-INSTITUTION EXPERIENCE JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 4 IS - 1 SE - Original Articles DO - 10.4084/mjhid.2012.044 UR - https://www.mjhid.org/mjhid/article/view/2012.044 SP - e2012044 AB - <p>Patients with chronic immune thrombocytopenia treated with romiplostim may benefit from a higher starting dose when a rapid increase in count is needed, but it could be avoided in those with a prompt response to the standard dosage. We hypothesized that a platelet count ? 20 x 10<sup>9</sup>/l at baseline could distinguish subjects with such response from those with a delayed one during the early phase of treatment. Our work is a retrospective and single-institution analysis comparing the median platelet count, the median weekly dosage of romiplostim and the median number of weekly platelet counts &lt; 50 x 10<sup>9</sup>/l between patients with a baseline ? 20 x 10<sup>9</sup>/l platelets (n=10, 2 splenectomized) and those with a lower one (n=8, 3 splenectomized) during the first month of treatment with romiplostim. The results show a higher median platelet count (79,5 vs 40,5 x 10<sup>9</sup>/l, p=0,002) and a lower median dose of romiplostim (1 vs 2 mcg/kg/week, p=0,01) in subjects with a baseline ? 20 x 10<sup>9</sup>/l  platelets, who also had a trend of less weekly counts &lt; 50  x 10<sup>9</sup>/l  platelets (1 vs 2, p=0,054). These data suggest that patients with ? 20 x 10<sup>9</sup>/l platelets at baseline may achieve a prompt response with the standard dose of romiplostim, but further and larger data are needed in order to assess whether it can be considered in clinical practice.</p> ER -