TY - JOUR AU - Teofili, Luciana PY - 2019/02/25 Y2 - 2024/03/28 TI - CORD BLOOD PLATELET LYSATE: IN VITRO EVALUATION TO SUPPORT THE USE IN REGENERATIVE MEDICINE.: Cord and adult blood platelet lysates JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 11 IS - 1 SE - Original Articles DO - 10.4084/mjhid.2019.021 UR - https://www.mjhid.org/mjhid/article/view/2019.021 SP - e2019021 AB - <p>Platelet-rich plasma (PRP) is an inexpensive and safe substitute of recombinant growth factors in Vitro and <em>in vivo</em>. Due to its putative effect on tissue repair, the use of autologous PRP has become largely popular. Recently, a jellified PRP derivative obtained from umbilical cord blood (CB) has been utilized <em>in vivo&nbsp;</em>to treat mucosal and cutaneous lesions. Nevertheless, whether PRP derived from CB and adult blood display different potency in promoting cell growth in Vitro has been rarely investigated. In this study, we compared cytokine profile and mesenchymal cell growth supporting the ability of platelet lysate obtained from adult and cord blood. Our <em>in vitro&nbsp;</em>results strongly back the utilization of CB platelet lysate <em>in vivo</em>, as an efficacious, safe and inexpensive alternative to promote damaged tissue healing when the autologous PRP is contraindicated. Moreover, the policy of manufacturing CB platelet lysate can limit the current disposal of many collected CB units not suitable for transplant due to their low nucleated cell count.</p><p>&nbsp;</p><p>&nbsp;</p> ER -