TY - JOUR AU - Taurino, Daniela AU - Frigeni, Marco AU - Grassi, Anna AU - Cavallaro, Gianluca AU - Salmoiraghi, Silvia AU - Spinelli, Orietta AU - Rambaldi, Alessandro AU - Lussana, Federico PY - 2021/08/28 Y2 - 2024/03/29 TI - Concurrent diagnosis of acute myeloid leukemia and symptomatic COVID-19 infection: a case report successfully treated with Azacitidine-Venetoclax combination JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 13 IS - 1 SE - Case Reports DO - 10.4084/MJHID.2021.057 UR - https://www.mjhid.org/mjhid/article/view/4689 SP - e2021057 AB - <p>SARS-COV2 pandemic has caused profound challenges in health care systems worldwide. Patients affected by hematological neoplasms appear to be particularly at risk of developing COVID-19 complications, with unfavorable outcomes.</p><p>Here, we present the case of a 57-years-old woman diagnosed with severe COVID-19 pneumonia and concurrent acute myeloid leukemia (AML). At the time of diagnosis, it was decided to postpone leukemia therapy to enable adequate COVID-19 pneumonia treatment. When her conditions related to pneumonia improved, the combination of Azacitidine-Venetoclax was used as first-line treatment, instead of conventional intensive chemotherapy. At the end of the first two cycles, the patient showed complete remission, and a post-remission consolidation with allogeneic hematopoietic stem cell transplantation has been planned.</p><p>This case suggests that Azacytidine-Venetoclax induction may represent a valid and safe alternative to intensive chemotherapy in the challenging setting of patients with a concomitant diagnosis of AML and severe COVID-19 infection.</p> ER -