TY - JOUR AU - Testa, Ugo AU - Castelli , Germana AU - Pelosi, Elvira PY - 2022/08/27 Y2 - 2024/03/29 TI - CLONAL HEMATOPOIESIS: ROLE IN HEMATOLOGIC NON-HEMATOLOGIC MALIGNANCIES: CLONAL HEMATOPOIESIS AND MALIGNANCIES JF - Mediterranean Journal of Hematology and Infectious Diseases JA - Mediterr J Hematol Infect Dis VL - 14 IS - 1 SE - Review Articles DO - 10.4084/MJHID.2022.069 UR - https://www.mjhid.org/mjhid/article/view/5083 SP - e2022069 AB - <p>Hematopoietic stem cells (HSCs) ensure the coordinated and balanced production of all hematopoietic cell types throughout life. Aging is associated with a gradual decline of the self-renewal and regenerative potential of HSCs and with the development of clonal hematopoiesis. Clonal hematopoiesis of indeterminate potential (CHIP) is a term defining the clonal expansion of genetically variant hematopoietic cells bearing one or more gene mutations and/or structural variants (such as copy number alterations). &nbsp;CHIP increases exponentially with age and is associated with cancers, including hematologic neoplasia, cardiovascular and other diseases. The presence of CHIP consistently increases the risk of hematologic malignancy, particularly in individuals who have CHIP in association with peripheral blood cytopenia.</p><p><strong>&nbsp;</strong></p><p><em>Key words: </em>hematopoiesis, hematopoietic stem cells, clonal hematopoiesis, gene mutations, next generation sequencing.</p><p>&nbsp;</p><p>&nbsp;</p> ER -