Original Articles
Rukiyye Bulut1, İbrahim Erayman1, Ceren Eryılmaz Yaman1, Bahar Kandemir1, Pınar Belviranlı Keskin2, Esma Kepenek Kurt1 and Özcan Çeneli3.
1 Necmettin Erbakan University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Konya, Türkiye.
2 Konya City Hospital, Department of Infectious Diseases and Clinical Microbiology, Konya, Türkiye.
3 Necmettin Erbakan University Faculty of Medicine, Department of Hematology, Konya, Türkiye.
Table S1. Comparison of episodes with and without documented neutropenia duration
Variable | Missing duration (n=67) | Available duration (n=159) | p |
|---|---|---|---|
Age (years), median (Q1-Q3) | 63 (46-71) | 61 (46-69) | 0.212ᵃ |
Sex, n (%) | 0.050ᵇ | ||
Female | 25 (37.3) | 82 (51.6) | |
Male | 42 (62.7) | 77 (48.4) | |
Acute leukemia/MDS group, n (%) | 0.452ᵇ | ||
No | 28 (41.8) | 58 (36.5) | |
Yes | 39 (58.2) | 101 (63.5) | |
Infection classification, n (%) | 0.055ᵇ | ||
Clinically documented infection | 19 (28.4) | 47 (29.6) | |
Microbiologically documented infection | 11 (16.4) | 48 (30.2) | |
Fever of unknown origin | 37 (55.2) | 64 (40.3) | |
Clinically suspected IPA, n (%) | 0.371ᵇ | ||
No | 60 (89.6) | 148 (93.1) | |
Yes | 7 (10.4) | 11 (6.9) | |
Fungal infection*, n (%) | 0.373ᵇ | ||
No | 59 (88.1) | 146 (91.8) | |
Yes | 8 (11.9) | 13 (8.2) |
This table presents a descriptive comparison of classical FN episodes by availability of neutropenia-duration data. ᵃ Mann-Whitney U test. ᵇ Pearson chi-square test. IPA, invasive pulmonary aspergillosis. *Fungal infection included clinically suspected invasive pulmonary aspergillosis and candidemia identified during the FN episode. Table S2. Univariable logistic regression analysis of factors associated with 28-day infection-related mortality in the acute leukemia/MDS group (n=81)
Variable | OR | 95% CI | p |
|---|---|---|---|
Female sex (ref: male) | 2.398 | 0.574-10.000 | 0.230 |
Age (years) | 1.017 | 0.977-1.059 | 0.409 |
Absolute neutrophil count (×10³/µL) | 0.438 | 0.014-13.454 | 0.637 |
Absolute lymphocyte count (×10³/µL) | 0.436 | 0.090-2.121 | 0.304 |
Platelet count (×10³/µL) | 0.978 | 0.945-1.013 | 0.209 |
CRP (mg/L) | 1.000 | 0.994-1.006 | 0.886 |
PCT (ng/mL) | 1.005 | 0.993-1.016 | 0.423 |
Duration of neutropenia (days) | 1.000 | 0.970-1.030 | 0.983 |
Clinically suspected IPA (ref: no) | 1.204 | 0.130-11.181 | 0.870 |
Analysis was restricted to patients in the acute leukemia/MDS group(AML, ALL, or MDS). Given the limited number of infection-related deaths (n=10), a multivariable model was not constructed. IPA, invasive pulmonary aspergillosis. CRP, C-reactive protein; PCT, procalcitonin. Table S3. Univariable and multivariable logistic regression analysis of factors associated with 28-day infection-related mortality in the full cohort (n=169)
Variable | Univariable OR (95% CI) | p | Adjusted OR (95% CI) | p |
|---|---|---|---|---|
Age (years) | 1.013 (0.982-1.046) | 0.411 | – | – |
Female sex (ref: male) | 2.079 (0.764-5.657) | 0.152 | 1.800 (0.646-5.015) | 0.261 |
Absolute neutrophil count (×10³/µL) | 1.002 (0.967-1.038) | 0.921 | – | – |
Absolute lymphocyte count (×10³/µL) | 0.981 (0.902-1.066) | 0.647 | – | – |
Platelet count (×10³/µL) | 0.985 (0.970-1.001) | 0.067 | 0.987 (0.971-1.003) | 0.103 |
CRP (mg/L) | 0.999 (0.994-1.003) | 0.600 | – | – |
PCT (ng/mL) | 1.002 (0.991-1.013) | 0.711 | – | – |
Duration of neutropenia (days) | 1.005 (0.980-1.031) | 0.677 | – | – |
Clinically suspected IPA (ref: no) | 3.575 (0.856-14.933) | 0.081 | – | – |
Acute leukemia/MDS group (ref: other hematological malignancies) | 1.728 (0.617-4.846) | 0.298 | 1.218 (0.415-3.573) | 0.720 |
The full cohort included the 13 patients excluded from the primary cohort because their index episode did not meet the conventional FN definition. Hosmer-Lemeshow χ²=7.93, df=8, p=0.440; Nagelkerke R²=0.080. The multivariable model used the same covariate specification as the primary analysis and included female sex, platelet count, and acute leukemia/MDS group. The acute leukemia/MDS group comprised patients with AML, ALL, and MDS, with other hematological malignancies serving as the reference category. CRP, C-reactive protein; PCT, procalcitonin; IPA, invasive pulmonary aspergillosis.