Case Reports
Vol. 10 (2018): Review Articles, Original Articles, Scientific Letters, Case Reports
https://doi.org/10.4084/mjhid.2018.019

Chemotherapy-colchicine interaction in a child with Familial Mediterranean Fever and Hodgkin Lymphoma

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Received: December 6, 2017
Accepted: January 15, 2018
Published: March 1, 2018
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Hodgkin lymphoma, familial Mediterranean fever, colchicine
Oncology

Authors

Karin Petra Sabine Langenberg-Ververgaert
karin.langenberg@sickkids.ca
Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Canada.
Ronald M. Laxer
Division of Rheumatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., .
Angela S. Punnett
Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., .
Lee L Dupuis
Department of Pharmacy, The Hospital for Sick Children, Toronto, Canada. Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Canada. Research Institute, The Hospital for Sick Children, Toronto, Canada., Canada.
Yaron Finkelstein
The Hospital for Sick Children, University of Toronto, Toronto, Canada., Canada.
Oussama Abla
Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., .

Familial Mediterranean Fever (FMF) has been associated with hematological malignancies, but has not been reported in association with Hodgkin lymphoma (HL). We hereby describe the first pediatric patient with FMF and stage IIA nodular sclerosis HL. She was treated with prednisone, doxorubicin, vincristine and etoposide (OEPA). However, she suffered more than expected treatment-related toxicity due to interaction with colchicine. Colchicine had to be discontinued during her second cycle of chemotherapy which was well tolerated. She is currently in remission at 17 months after her HL diagnosis, and her FMF is under control with colchicine without any signs of toxicity.

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Ethics Approval

Case Report
Karin Petra Sabine Langenberg-Ververgaert, Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Angela S. Punnett, Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Oussama Abla, Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

How to Cite



“Chemotherapy-colchicine interaction in a child with Familial Mediterranean Fever and Hodgkin Lymphoma” (2018) Mediterranean Journal of Hematology and Infectious Diseases, 10(1), p. e2018019. doi:10.4084/mjhid.2018.019.