A rare case of multidrug resistant Leclercia adecarboxylata catheter-related bloodstream infection and an updated brief literature review Leclercia adecarboxylata catheter-related bloodstream infection.

Main Article Content

Cosimo Colangelo
Giorgio Tiecco
Marco Di Gregorio
Susanna Capone
Roberto Luigi Allegri
Maria De Francesco
Francesca Caccuri
Arnaldo Caruso
Francesco Castelli
Emanuele Focà

Keywords

Leclercia, Leclercia, adecarboxylata, MDR, CRBSI, CATHETER RELATED BLOODSTREAM INFECTION

Abstract

Leclercia adecarboxylata is a gram-negative bacillus, a ubiquitous microorganism, which may be found in both aquatic environments and soil, it was first described by H. Leclerc in 1962 and was reclassified thanks to more sensitive testing methods. L. adecarboxylata has been recently recognized as an emerging pathogen that causes several clinical syndromes not only in immunocompromised patients. 

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References

1. Malik K, Davie R, Withers A, Faisal M, Lawal F. A case of Leclercia adecarboxylata endocarditis in a 62-year-old man. IDCases. 2021 Mar 27;24: e01091. doi: 10.1016/j.idcr. 2021.e01091. PMID: 33889491; PMCID: PMC8047457.
2. Zayet S, Lang S, Garnier P, Pierron A, Plantin J, Toko L, Royer PY, Villemain M, Klopfenstein T, Gendrin V. Leclercia adecarboxylata as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing. Pathogens. 2021 Oct 28;10(11):1399. doi: 10.3390/pathogens10111399. PMID: 34832555; PMCID: PMC8619052.
3. Anuradha M. Leclercia adecarboxylata isolation: case reports and review. J Clin Diagn Res. 2014 Dec;8(12):DD03-4. doi: 10.7860/JCDR/2014/9763.5260. Epub 2014 Dec 5. PMID: 25653951; PMCID: PMC4316257.
4. Spiegelhauer MR, Andersen PF, Frandsen TH, Nordestgaard RLM, Andersen LP. Leclercia adecarboxylata: a case report and literature review of 74 cases demonstrating its pathogenicity in immunocompromised patients. Infect Dis (Lond). 2019 Mar;51(3):179-188. doi: 10.1080/23744235.2018.1536830. Epub 2018 Nov 29. PMID: 30488747.
5. Alosaimi RS, Muhmmed Kaaki M. Catheter-Related ESBL-Producing Leclercia adecarboxylata Septicemia in Hemodialysis Patient: An Emerging Pathogen? Case Rep Infect Dis. 2020 Jan 21;2020:7403152. doi: 10.1155/2020/7403152. PMID: 32089912; PMCID: PMC6996699.
6. Broderick A, Lowe E, Xiao A, Ross R, Miller R. Leclercia adecarboxylata folliculitis in a healthy swimmer-An emerging aquatic pathogen? JAAD Case Rep. 2019 Aug 5;5(8):706-708. doi: 10.1016/j.jdcr.2019.06.007. PMID: 31440563; PMCID: PMC6698442.
7. De Mauri A, Chiarinotti D, Andreoni S, Molinari GL, Conti N, De Leo M. Leclercia adecarboxylata and catheter-related bacteraemia: review of the literature and outcome with regard to catheters and patients. J Med Microbiol. 2013 Oct;62(Pt 10):1620-1623. doi: 10.1099/jmm.0.059535-0. Epub 2013 Jul 23. PMID: 23882033.
8. Shaikhain T, Al-Husayni F, Al-Fawaz S, Alghamdi EM, Al-Amri A, Alfares M. Leclercia adecarboxylata Bacteremia without a Focus in a Non-Immunosuppressed Patient. Am J Case Rep. 2021 Mar 30;22:e929537. doi: 10.12659/AJCR.929537. PMID: 33782375; PMCID: PMC8019838.
9. Bali R, Sharma P, Gupta K, Nagrath S. Pharyngeal and peritonsillar abscess due to Leclercia adecarboxylata in an immunocompetant patient. J Infect Dev Ctries. 2013 Jan 15;7(1):46-50. doi: 10.3855/jidc.2651. PMID: 23324820.
10. Shin GW, You MJ, Lee HS, Lee CS. Catheter-related bacteremia caused by multidrug-resistant Leclercia adecarboxylata in a patient with breast cancer. J Clin Microbiol. 2012 Sep;50(9):3129-32. doi: 10.1128/JCM.00948-12. Epub 2012 Jul 3. PMID: 22760051; PMCID: PMC3421816.
11. Gajdács, M.; Ábrók, M.; Lázár, A.; Terhes, G.; Burián, K. Leclercia adecarboxylata as an emerging pathogen in human infections: A 13-year retrospective analysis in Southern Hungary. J. Infect. Dev. Ctries. 2020, 14, 1004–1010.
12. Stock I, Burak S, Wiedemann B. 2004. Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. Clin. Microbiol. Infect. 10:724 –733.
13. Garza-González E, Bocanegra-Ibarias P, Rodríguez-Noriega E, González-Díaz E, SilvaSanchez J, Garza-Ramos U, Contreras-Coronado-Tovar IF, Santos-Hernández JE, Gutiérrez Bañuelos D, Mena-Ramirez JP, Ramírez-De-Los-Santos S, Camacho-Ortiz A, Morfín-Otero R. Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata. BMC Infect Dis. 2021 Feb 28;21(1):235. doi: 10.1186/s12879-021-05923-0. PMID: 33639886; PMCID: PMC7916303.
14. Hess B, Burchett A, Huntington MK. Leclercia adecarboxylata in an immunocompetent patient. J Med Microbiol. 2008 Jul;57(Pt 7):896-898. doi: 10.1099/jmm.0.47673-0. PMID: 18566150.
15. Hurley EH, Cohen E, Katarincic JA, Ohnmacht RK. Leclercia Adecarboxylata Infection in an Immunocompetent Child. R I Med J (2013). 2015 Sep 1;98(9):41-4. PMID: 26324975.
16. A. Mazzariol, J. Zuliani, R. Fontana, and G. Cornaglia, “Isolation from blood culture of a Leclercia adecarboxylata strain producing an SHV-12 extended-spectrum beta-lactamase,” Journal of Clinical Microbiology, vol. 41, no. 4, pp. 1738-1739, 2003.
17. Lee, B.; Sir, J.-J.; Park, S.-W.; Kwak, C.-H.; Kim, S.-M.; Kim, S.-B.; Cho, W.H.; Choi, S.-K.; Kwak, Y.G.; Whang, D.H. A Case of Leclercia adecarboxylata Endocarditis in a Woman with Endometrial Cancer. Am. J. Med. Sci. 2009, 337, 146–147.
18. Li, J.; Park, A.; Fulmer, B.R.; Garg, T. Leclercia adecarboxylata urinary tract infection in a patient with bladder cancer and recurrent hematuria. Urol. Case Rep. 2021, 36, 101579.
19. Ravikumar, R.; Patra, N.; Indiradevi, B. Prakash Hospital-acquired pneumonia due to Leclercia adecarboxylata in a neurosurgical centre. J. Postgrad. Med. 2015, 61, 123–125.
20. Hassan, I.; Gupta, P.; Ray, P.; Tiewsoh, K. Leclercia adecarboxylata Causing Spontaneous Bacterial Peritonitis in a Child with Nephrotic Syndrome: A Case Report and Review of Literature. J. Lab. Physicians 2020, 12, 222–224.
21. Adapa, S.; Konala, V.M.; Nawaz, F.; Javed, T.; Dhingra, H.; Gutierrez, I.A.; Ramirez, M.L. Peritonitis from Leclercia adecarboxylata: An emerging pathogen. Clin. Case Rep. 2019, 7, 829–831.
22. Riazzo C, López-Cerero L, Rojo-Martín MD, Hoyos-Mallecot Y, Fernández-Cuenca F, Martín-Ruíz JL, Pascual-Hernández Á, Naas T, Navarro-Marí JM. First report of NDM-1-producing clinical isolate of Leclercia adecarboxylata in Spain. Diagn Microbiol Infect Dis. 2017 Jul;88(3):268-270. doi: 10.1016/j.diagmicrobio.2017.04.013. Epub 2017 May 3. PMID: 28506721.